Place Your BETs in Combination Therapy.

Mol Cell

Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, VIC 3052, Australia; Centre for Cancer Research, University of Melbourne, Melbourne, Australia. Electronic address:

Published: June 2020

AI Article Synopsis

  • Combination therapy is essential for effectively managing cancer, requiring a strategic pairing of drugs.
  • Shu et al. (2020) present an advanced multi-omic study to discover pathways that work together to enhance the effectiveness of BET bromodomain inhibitors.
  • Their research focuses specifically on improving treatment outcomes for triple-negative breast cancer patients.

Article Abstract

Combination therapy remains the cornerstone for cancer management, and understanding how to rationally partner drugs is imperative. In this issue of Molecular Cell, Shu et al. (2020) provide a tour de force multi-omic approach to identify synergistic pathways that increase the efficacy of BET bromodomain inhibitors in triple-negative breast cancer.

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Source
http://dx.doi.org/10.1016/j.molcel.2020.05.026DOI Listing

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