An unprecedented nickel-catalyzed hydroarylative and hydroalkenylative cyclization of unsymmetrically substituted 1,6-dienes with organoboronic acid was developed by using MeOH as the hydrogen source and employing commercially available Ni(η-1,5-cyclooctadiene) as the catalyst. A series of biologically interesting cyclic products were afforded in moderate to excellent yields with high regio- and diastereoselectivities.
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Nickel-catalyzed regio- and diastereoselective hydroarylative and hydroalkenylative cyclization of 1,6-dienes.
Chem Commun (Camb)
July 2020
Chang-Kung Chuang Institute, Shanghai Key Laboratory of Green Chemistry and Chemical Process, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200241, China.
An unprecedented nickel-catalyzed hydroarylative and hydroalkenylative cyclization of unsymmetrically substituted 1,6-dienes with organoboronic acid was developed by using MeOH as the hydrogen source and employing commercially available Ni(η-1,5-cyclooctadiene) as the catalyst. A series of biologically interesting cyclic products were afforded in moderate to excellent yields with high regio- and diastereoselectivities.
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