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The Ability of Combined Flavonol and Trihydroxyorganic Acid to Suppress SARS-CoV-2 Reproduction.
Viruses
December 2024
Scientific Research Institute for Biological Safety Problems, Ministry of Health of Kazakhstan, Almaty 080409, Kazakhstan.
The global burden of COVID-19 continues to rise, and despite significant progress in vaccine development, there remains a critical need for effective treatments for the severe inflammation and acute lung injury associated with SARS-CoV-2 infection. In this study, we explored the antiviral properties of a plant-derived complex consisting of flavonol and hydroxyorganic acid compounds. Our research focused on the ability of the flavonol and hydroxyorganic acid complex to suppress the activity of several key proteins involved in the replication and maturation of SARS-CoV-2.
View Article and Find Full Text PDFPredicting the Anti-SARS-CoV-2 Potential of Isoquinoline Alkaloids from Brazilian Siparunaceae Species Using Chemometric Tools.
Int J Mol Sci
January 2025
Instituto de Pesquisas de Produtos Naturais, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, RJ, Brazil.
The COVID-19 pandemic has caused over 7 million deaths globally in the past four years. spp. (Siparunaceae), which is used in Brazilian folk medicine, is considered a genus with potential antiviral alternatives.
View Article and Find Full Text PDFLived Experiences of Self-Care in Older Adults with Lymphoma Undergoing Chemotherapy Treatments During the COVID-19 Pandemic.
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January 2025
Bloomberg Faculty of Nursing, University of Toronto, Toronto, ON M4C 4V9, Canada.
To be diagnosed and treated for cancer can be a distressing experience, and it can require individuals to engage in self-care strategies to cope with the situation. The self-care experiences of older adults with lymphoma undergoing chemotherapy during the COVID-19 pandemic in Thailand remain rarely studied. This study aimed to explore the lived experiences of self-care among older adults with lymphoma undergoing chemotherapy during the COVID-19 pandemic.
View Article and Find Full Text PDFUnveiling the broad spectrum efficacy of volatile terpenes to fight against SARS-COV-2-associated mucormycosis.
Chem Biodivers
January 2025
Deraya University, Pharmacognosy, New Minia, New Minia, EGYPT.
Mucormycosis, a life-threatening fungal infection caused by Mucorales, affects immunocompromised patients, especially SARS-CoV-2 ones. Existing antifungal therapies, like amphotericin B, have serious health risks. The current study reviews the literature regarding an overview of SARS-CoV-2-associated mucormycosis, along with different terpenes from diverse edible sources such as basil, ginger, and clove, which are detected till June 2024.
View Article and Find Full Text PDFHow to implement pairing assistance during fighting COVID-19 in China: collaborative governance between local governments under the authoritative regulation.
Front Public Health
January 2025
School of Public Policy and Management, China University of Mining and Technology, Xuzhou, China.
Background: The pairing assistance policy represents a distinctive instrument utilized by the Chinese government to address major public crises. This study examines the development of a pairing assistance policy by the Chinese Government through its central authority to foster collaborative governance among local governments in areas affected by COVID-19.
Methods: The aim of the study was to gain a clear understanding of how the policy of pairing assistance in public health emergencies is successfully implemented through the top-down application of authority.
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