The major roles of keratin 17 (K17) as a prognostic biomarker have been highlighted in a range of human malignancies. However, its relevance to esophageal squamous cell carcinoma (ESCC) remains unexplored. In this study, the relationship between K17 expression and clinicopathologic parameters and survival were determined by RNA sequencing (RNA-Seq) in 90 ESCCs and by immunohistochemistry (IHC) in 68 ESCCs. K17 expression was significantly higher in ESCC than in paired normal tissues at both the messenger RNA and protein levels. K17 messenger RNA and staining by IHC were significantly correlated with aggressive characteristics, including advanced clinical stage, invasion depth, and lymph node metastases; and were predictive of poor prognosis in advanced disease patients. Furthermore, K17 expression was detected by IHC in high-grade premalignant lesions of the esophageal mucosa, suggesting that K17 could also be a biomarker of dysplasia of the esophageal mucosa. Overall, this study established that K17 is a negative prognostic biomarker for the most common subtype of esophageal cancer.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/PAI.0000000000000862 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Validation of Keratin 17 as a tissue biomarker in the diagnosis of upper tract urothelial carcinoma.
Hum Pathol
November 2024
Department of Pathology, University of California Irvine Medical Center, 101 The City Dr. South, Orange, 92868, CA, USA. Electronic address:
Article Synopsis
- Upper tract urothelial carcinoma (UTUC) presents diagnostic and treatment challenges, highlighting the need for new biomarkers for tumor detection.
- * In a study of 139 UTUC cases, Keratin 17 (KRT17) showed significantly higher expression in malignant tumors compared to normal tissue, particularly in noninvasive and invasive forms.
- * The KRT17 marker demonstrated strong sensitivity (91%) and specificity (69%) for distinguishing benign from malignant tumors, suggesting its potential utility in future diagnostic practices.
The expression of keratin 17 and p27 predicts clinical outcomes in colorectal cancer.
APMIS
January 2025
Department of Pathology, Chung-Ang University Hospital, College of Medicine, Chung-Ang University, Seoul, South Korea.
Keratin 17 (K17) is frequently overexpressed, associated with poor prognosis in various cancers, and contributes to p27 degradation during cancer progression. Using immunohistochemistry, we evaluated K17 and p27 expression and assessed their biological behavior and prognostic significance in 326 colorectal cancers. High K17 expression was associated with poorly differentiated tumors, high pT classification, and lymph node metastases.
View Article and Find Full Text PDFAcetylation of DnaJ facilitates the proliferation of BmNPV by affecting the transport of nucleocapsids.
Microb Pathog
December 2024
Institute of Biochemistry, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Zhejiang Province, Hangzhou, 310018, PR China; Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine, Zhejiang Province, Hangzhou, 310018, PR China. Electronic address:
Article Synopsis
- DnaJ (Orf40) is a key protein in the Bombyx mori nucleopolyhedrovirus that is crucial for the budding of new virus particles and transporting nucleocapsids from the nucleus to the cytoplasm.
- Previous research showed that reducing DnaJ levels prevents nucleocapsids from leaving the nucleus, but how this process is regulated was not clear.
- Our study found that acetylation of a specific lysine residue (K17) in DnaJ enhances viral replication by improving nucleocapsid interaction with proteins and their transport within the cell, while deacetylation disrupts this process and reduces virus production.
Keratin 17 and A2ML1 are negative prognostic biomarkers in non-small cell lung cancer.
Pathol Res Pract
November 2024
Department of Pathology, Renaissance School of Medicine, Stony Brook, NY 11794, USA. Electronic address:
Although the overall prognosis for patients with non-small cell lung cancer (NSCLC) has improved over the past several decades, there are still survival differences that are not accurately defined by clinicopathological factors. Thus, there is an unmet clinical need to develop novel approaches to enhance prognostic accuracy for these patients. Keratin 17 (K17) is a negative prognostic biomarker in a wide range of cancer types, including pancreatic ductal adenocarcinoma, head and neck squamous cell carcinoma, and pulmonary adenocarcinoma (LUAD), but has yet to be investigated as a prognostic biomarker in primary lung squamous cell carcinoma (LSCC).
View Article and Find Full Text PDFInhibition of KPNA2 by ivermectin reduces E2F1 nuclear translocation to attenuate keratinocyte proliferation and ameliorate psoriasis-like lesions.
Int Immunopharmacol
December 2024
State Key Laboratory of Analytical Chemistry for Life Science & Jiangsu Key Laboratory of Molecular Medicine, Medical School, Nanjing University, Nanjing 210093, PR China. Electronic address:
Article Synopsis
- * Using ivermectin, which inhibits KPNA2, significantly improved psoriasis symptoms in mice by reducing redness, scaling, and thickness of the skin, alongside lower levels of KPNA2 and markers of skin cell growth.
- * The research also showed that reducing KPNA2 affected key signaling pathways in skin cells, suggesting it plays a crucial role in the development of psoriasis and could be a viable target for new treatments in the future.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!