COVID-19 Neurologic Complication with CNS Vasculitis-Like Pattern.

AJNR Am J Neuroradiol

Departments of Interventional Radiology (R.H.), Cardiothoracic, Vascular and Respiratory Intensive Care (P.-A.R.), Neurology and Neurophysiology (B.P.), and Neuroradiology (N.D., F.D., D.M., J.-M.C.), University Hospital of Amiens, Amiens, France.

Published: August 2020

Coronavirus disease 2019 (COVID-19) is a viral infection caused by the Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2), which spreads rapidly from person to person and manifests in most symptomatic patients as a respiratory illness, similar to prior SARS viruses. Neurologic manifestations of COVID-19 are uncommon; those so far reported include encephalopathy, stroke from large-vessel occlusion, and polyneuropathy. We report a unique neurologic complication of COVID-19 in a patient who had extensive cerebral small-vessel ischemic lesions resembling cerebral vasculitis in a characteristic combined imaging pattern of ischemia, hemorrhage, and punctuate postcontrast enhancement. Also, a characteristic lower extremity skin rash was present in our patient. Our observation lends support to the increasingly suspected mechanism of "endotheliitis" associated with this novel coronavirus.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7658880PMC
http://dx.doi.org/10.3174/ajnr.A6651DOI Listing

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