AI Article Synopsis
- The research focused on creating controlled drug delivery systems using chitosan nanoparticles (CSNPs) to deliver antibiotic drugs like tetracycline, gentamycin, and ciprofloxacin effectively.
- CSNPs were produced through ionic gelation with tripolyphosphate, resulting in antibiotic-loaded nanocomposites that demonstrated strong antibacterial properties with low toxicity.
- Treated fabrics, including 100% cotton and a cotton/polyester blend, displayed effective inhibition of both Gram-positive and Gram-negative bacteria, as confirmed by FTIR and SEM analyses showing the integration of nanoparticles with the fabrics.
Article Abstract
The main aim of this research work was to develop controlled drug delivery systems based on nanotechnology. Chitosan nanoparticles (CSNPs) were selected as a nanocarrier for the selected antibiotic drugs tetracycline, gentamycin and ciprofloxacin. CSNPs were prepared from chitosan solution by using tripolyphosphate (TPP) via ionic gelation method. Then the prepared high performance CSNPs were loaded with three different antibiotics to form nanocomposite from antibiotic loaded chitosan nanoparticles. Then the prepared nanocomposite used as superior antibacterial materials with minimum toxicity. Samples of cotton (100%) and (50:50) cotton/polyester blended fabrics were treated with different concentrations of this composite to impart antibacterial activity. Results showed that the treated fabrics with chitosan nanoparticles and its nanocomposite with different antibiotics were inhibited the growth of both Gram-positive and Gram-negative bacteria. The Fourier Transform Infrared spectroscopy (FTIR) and Scanning Electron Microscope (SEM) analysis exposed the embedding of chitosan nanoparticles into fabrics and their antibiotics loaded.
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| http://dx.doi.org/10.1016/j.ijbiomac.2020.06.118 | DOI Listing |
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