Parallel Parabrachial Pathways Provide Pieces of the Pain Puzzle.

Neuron

National Center for Complementary and Integrative Health, National Institutes of Health, Bethesda, MD 20892, USA; National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address:

Published: June 2020

Noxious stimuli evoke a range of acute and long-lasting sensations, emotions, and behaviors. In this issue of Neuron, Chiang et al. (2020) demonstrate that parallel outputs from the lateral parabrachial nucleus arise from specific cell types with distinct functions in pain.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8794003PMC
http://dx.doi.org/10.1016/j.neuron.2020.05.034DOI Listing

Publication Analysis

Top Keywords

parallel parabrachial
4
parabrachial pathways
4
pathways provide
4
provide pieces
4
pieces pain
4
pain puzzle
4
puzzle noxious
4
noxious stimuli
4
stimuli evoke
4
evoke range
4

Similar Publications

A parabrachial-hypothalamic parallel circuit governs cold defense in mice.

Nat Commun

August 2023

Shanghai Institute for Advanced Immunochemical Studies & School of Life Science and Technology, Shanghaitech University, Shanghai, 201210, China.

Thermal homeostasis is vital for mammals and is controlled by brain neurocircuits. Yet, the neural pathways responsible for cold defense regulation are still unclear. Here, we found that a pathway from the lateral parabrachial nucleus (LPB) to the dorsomedial hypothalamus (DMH), which runs parallel to the canonical LPB to preoptic area (POA) pathway, is also crucial for cold defense.

View Article and Find Full Text PDF

The brain is able to amplify or suppress nociceptive signals by means of descending projections to the spinal and trigeminal dorsal horns from the rostral ventromedial medulla (RVM). Two physiologically defined cell classes within RVM, "ON-cells" and "OFF-cells," respectively facilitate and inhibit nociceptive transmission. However, sensory pathways through which nociceptive input drives changes in RVM cell activity are only now being defined.

View Article and Find Full Text PDF

Parabrachial Nucleus Activity in Nociception and Pain in Awake Mice.

J Neurosci

August 2023

Program in Neuroscience, Department of Neurobiology, School of Medicine, University of Maryland, Baltimore, Maryland 21201

The parabrachial nuclear complex (PBN) is a nexus for aversion and for the sensory and affective components of pain perception. We have previously shown that during chronic pain PBN neurons in anesthetized rodents have amplified activity. We report a method to record from PBN neurons of behaving, head-restrained mice while applying reproducible noxious stimuli.

View Article and Find Full Text PDF

Unlabelled: The parabrachial nuclear complex (PBN) is a nexus for aversion, and for the sensory and affective components of pain perception. We have previously shown that, during chronic pain, PBN neurons in anesthetized rodents have amplified activity. We report a method to record from PBN neurons of behaving, head-restrained mice, while applying reproducible noxious stimuli.

View Article and Find Full Text PDF

Photoaffinity ligands are best known as tools used to identify the specific binding sites of drugs to their molecular targets. However, photoaffinity ligands have the potential to further define critical neuroanatomic targets of drug action. In the brains of WT male mice, we demonstrate the feasibility of using photoaffinity ligands to prolong anesthesia via targeted yet spatially restricted photoadduction of azi--propofol (aziPm), a photoreactive analog of the general anesthetic propofol.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!