Noxious stimuli evoke a range of acute and long-lasting sensations, emotions, and behaviors. In this issue of Neuron, Chiang et al. (2020) demonstrate that parallel outputs from the lateral parabrachial nucleus arise from specific cell types with distinct functions in pain.
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http://dx.doi.org/10.1016/j.neuron.2020.05.034 | DOI Listing |
Nat Commun
August 2023
Shanghai Institute for Advanced Immunochemical Studies & School of Life Science and Technology, Shanghaitech University, Shanghai, 201210, China.
Thermal homeostasis is vital for mammals and is controlled by brain neurocircuits. Yet, the neural pathways responsible for cold defense regulation are still unclear. Here, we found that a pathway from the lateral parabrachial nucleus (LPB) to the dorsomedial hypothalamus (DMH), which runs parallel to the canonical LPB to preoptic area (POA) pathway, is also crucial for cold defense.
View Article and Find Full Text PDFJ Neurosci
August 2023
Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, Oregon 97239
The brain is able to amplify or suppress nociceptive signals by means of descending projections to the spinal and trigeminal dorsal horns from the rostral ventromedial medulla (RVM). Two physiologically defined cell classes within RVM, "ON-cells" and "OFF-cells," respectively facilitate and inhibit nociceptive transmission. However, sensory pathways through which nociceptive input drives changes in RVM cell activity are only now being defined.
View Article and Find Full Text PDFJ Neurosci
August 2023
Program in Neuroscience, Department of Neurobiology, School of Medicine, University of Maryland, Baltimore, Maryland 21201
The parabrachial nuclear complex (PBN) is a nexus for aversion and for the sensory and affective components of pain perception. We have previously shown that during chronic pain PBN neurons in anesthetized rodents have amplified activity. We report a method to record from PBN neurons of behaving, head-restrained mice while applying reproducible noxious stimuli.
View Article and Find Full Text PDFbioRxiv
May 2023
University of Maryland, Program in Neuroscience, Department of Neurobiology.
Unlabelled: The parabrachial nuclear complex (PBN) is a nexus for aversion, and for the sensory and affective components of pain perception. We have previously shown that, during chronic pain, PBN neurons in anesthetized rodents have amplified activity. We report a method to record from PBN neurons of behaving, head-restrained mice, while applying reproducible noxious stimuli.
View Article and Find Full Text PDFJ Neurosci
March 2023
Department of Anesthesiology and Critical Care, University of Pennsylvania Perelman School of Medicine, Philadelphia, Philadelphia 19104
Photoaffinity ligands are best known as tools used to identify the specific binding sites of drugs to their molecular targets. However, photoaffinity ligands have the potential to further define critical neuroanatomic targets of drug action. In the brains of WT male mice, we demonstrate the feasibility of using photoaffinity ligands to prolong anesthesia via targeted yet spatially restricted photoadduction of azi--propofol (aziPm), a photoreactive analog of the general anesthetic propofol.
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