Endurance exercise drives physiological changes in the muscle to optimize performance. In a recent study in Science, Knudsen et al. report a role for the type 2 cytokine interleukin-13 in orchestrating metabolic reprogramming that drives adaptation to endurance exercise.
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Nutritional Intake and Timing of Marathon Runners: Influence of Athlete's Characteristics and Fueling Practices on Finishing Time.
Sports Med Open
March 2025
Nursing Department, Faculty of Health Sciences, University of Alicante, 03690, Alicante, Spain.
Background: Endurance athletes' competitions have increased over the decades and marathon races are becoming increasingly popular. Proper nutrition is critical for optimal performance and long-term health in marathon athletes. This study aimed to investigate runners' nutritional intake, especially fluids, food, and supplements, competing in the Seville Marathon.
View Article and Find Full Text PDFInhaled menthol for dyspnea relief during cycle exercise in COPD: a randomized trial.
Chest
March 2025
Research Group for Rehabilitation in Internal Disorders, Department of Rehabilitation Sciences, KU Leuven, Leuven, Belgium; Laboratory of Respiratory Diseases and Thoracic Surgery (BREATHE), Department of Chronic Diseases and Metabolism (CHROMETA), KU Leuven, Leuven, Belgium. Electronic address:
Background: Menthol inhalation (MI) lowers dyspnea ratings during loaded breathing in chronic obstructive pulmonary disease (COPD) and cycle exercise in healthy adults. Proposed mechanisms include stimulation of cold receptors in the upper airways, modulating perception of breathing-related effort and airflow.
Research Question: Does MI also alleviate exertional dyspnea in COPD?
Study Design And Methods: Twenty COPD patients (60% male, 68±6 years, FEV=47±17 %predicted) completed 2 constant-load cycle exercise tests (73±7 %peak power output) to exhaustion with menthol or placebo (strawberry flavoring) added to the breathing circuit in counter-balanced order and on separate days.
Dietary timing enhances exercise by modulating fat-muscle crosstalk via adipocyte AMPKα2 signaling.
Cell Metab
March 2025
Department of Cardiovascular Medicine, Center for Circadian Metabolism and Cardiovascular Disease, Southwest Hospital, Army Medical University, Chongqing 400038, China; Ministry of Education Key Laboratory of Geriatric Cardiovascular and Cerebrovascular Disease, Chongqing 400038, China. Electronic address:
Feeding rhythms regulate exercise performance and muscle energy metabolism. However, the mechanisms regulating adipocyte functions remain unclear. Here, using multi-omics analyses, involving (phospho-)proteomics and lipidomics, we found that day-restricted feeding (DRF) regulates diurnal rhythms of the mitochondrial proteome, neutral lipidome, and nutrient-sensing pathways in mouse gonadal white adipose tissue (GWAT).
View Article and Find Full Text PDFThe accuracy of fixed intensity anchors to estimate lactate thresholds in recreational runners.
Eur J Appl Physiol
March 2025
Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland.
Background: Endurance exercise intensities can be categorized into moderate, heavy, and severe domains based on physiological responses during incremental exercise testing. Since the evaluation of metabolic thresholds is not always possible, this study assessed the accuracy of fixed intensity anchors to estimate lactate thresholds.
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Pacing in ultra-marathon running: the Western States 100-mile endurance run 2006-2023.
Sci Rep
March 2025
Institute of Primary Care, University of Zurich, Zürich, Switzerland.
Pacing has been investigated in different running races, including ultra-marathons. We have, however, little knowledge about pacing in ultra-trail running. To date, no study has investigated pacing in one of the most iconic ultra-trail running races, the 'Western States 100-Mile Endurance Run' (WSER), which covers 160 km (100 miles) and includes significant elevation changes (6000 vertical meters uphill and 7500 vertical meters downhill).
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