AI Article Synopsis
- - The study aimed to investigate autoimmune hemolytic anemia triggered by salvianolate through antibody detection and monitoring of clinical indices.
- - Researchers employed a micro-column gel method to identify irregular antibodies and tested red blood cells sensitized with various substances against the patient's plasma.
- - Findings revealed that the patient exhibited anti-Ce antibodies and had positive results for red blood cells sensitized with salvianolate, confirming that salvianolate can induce drug-related autoimmune hemolytic anemia.
Article Abstract
Objective: To evaluate the characteristics of autoimmune hemolytic anemia caused by salvianolate by antibody detection and clinical index monitoring.
Methods: Micro-column gel anti-human globulin method was used for irregular antibody screening and antibody identification. Salvianolate, sodium creatine phosphate and levocarnitine were used to sensitize red blood cells that were compatible with the patient's plasma, and the RBCs were used to test drug antibody in patient plasma respectively. The patient's clinical examination of hemolysis index and blood transfusion effect were analyed retrospectively.
Results: The patients were positive for irregular antibody screening, and there were antoanti-Ce antibodies in serum. The erythrocytes sensitized with salvianolate in the patient's serum were positive, while those sensitized with sodium creatine phosphate and levocarnitine were negative.
Conclusion: Salvianolate causes drug-induced autoimmune hemolytic anemia in this patient.
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| http://dx.doi.org/10.19746/j.cnki.issn.1009-2137.2020.03.031 | DOI Listing |
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