AI Article Synopsis
- Glioblastoma multiforme (GBM) can spread to other parts of the body, like the scalp and lungs, but it doesn't happen very often.
- A 46-year-old man had GBM that spread from his brain to his scalp and then to his lungs, despite treatment.
- This case shows it's important for doctors to keep checking patients with GBM for signs of spreading, so they can give the best help possible.
Article Abstract
Extracranial metastasis from glioblastoma multiforme (GBM) is rare, especially multi-site metastases without intracranial recurrence. However, the metastatic mechanism of GBM remains unknown and there is currently no consensus regarding the best therapeutic regimen. We report the case of a 46-year-old man with primary GBM who developed scalp metastases and subsequent multiple pulmonary metastases. He was treated with the Stupp regimen after surgery for the intracranial tumor. However, a series of soft masses in the scalp were subsequently identified, and new nodules were found in his left eyebrow arch during chemoradiotherapy. Despite salvage chemotherapy and targeted therapy, the patient eventually died of respiratory failure with multiple pulmonary metastases. This case highlights the need for rigorous follow-up, including brain magnetic resonance imaging, in patients with GBM. The occurrence of extra-central nervous system symptoms indicates the possibility of metastasis, and the relevant examinations should be conducted promptly. Positive therapies may help to relieve symptoms and prolong survival in patients with metastatic GBM.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303784 | PMC |
| http://dx.doi.org/10.1177/0300060520930459 | DOI Listing |
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