Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7670500 | PMC |
| http://dx.doi.org/10.1161/JAHA.120.017170 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The Era of Antibody Drug Conjugates in Lung Cancer: Trick or Threat?
Cancer Res Treat
November 2024
Department of Cancer Medicine, Gustave Roussy Cancer Campus, Villejuif, France.
Antibody Drug Conjugates (ADCs) are a novel class of therapeutics that structurally are composed by an antibody directed to a tumour epitope connected via a linker to a cytotoxic payload, and that have shown significant antitumor activity across a range of malignancies including lung cancer. In this article we review the pharmacology and design of ADCs, as well as we describe the results of different studies evaluating ADCs in lung cancer directed to several targets including HER2, HER3, TROP2, MET, CEACAM5 and DLL3, among others.
View Article and Find Full Text PDFAntiviral Effect of Melatonin on Caco-2 Cell Organoid Culture: Trick or Treat?
Int J Mol Sci
November 2024
Department of Pediatrics, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania.
Melatonin is a hormone naturally produced by the body that has recently been found to have antiviral properties. However, its antiviral mechanisms are not entirely understood. Using Caco-2 cells, we developed a gastrointestinal organoid model to investigate the impact of melatonin on cellular organoid culture response to Poly I:C-induced viral inflammation in the gastrointestinal tract.
View Article and Find Full Text PDFExploiting protein domain modularity to enable synthetic control of engineered cells.
Curr Opin Biomed Eng
September 2024
School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta GA 303332, USA.
The ability to precisely control cellular function in response to external stimuli can enhance the function and safety of cell therapies. In this review, we will detail how the modularity of protein domains has been exploited for cellular control applications, specifically through design of multifunctional synthetic constructs and controllable split moieties. These advances, which build on techniques developed by biologists, protein chemists and drug developers, harness natural evolutionary tendencies of protein domain fusion and fission.
View Article and Find Full Text PDFCannabis use disorder: from neurobiology to treatment.
J Clin Invest
October 2024
Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada.
Cannabis has been legalized for medical and recreational purposes in multiple countries. A large number of people are using cannabis and some will develop cannabis use disorder (CUD). There is a growing recognition that CUD requires specific interventions.
View Article and Find Full Text PDFThe "Micro"cosm: Magnifying the Nuance of Low Dose Buprenorphine Inductions.
J Opioid Manag
September 2024
Background: Now that the X-wavier is a thing of the past, patients with Opioid Use Disorder (OUD) who previously lacked access to buprenorphine may have access to lower barrier care and may be looking to make the transition from either methadone or illicit fentanyl to buprenorphine. This can be quite challenging and both fentanyl and methadone are hihghly potent drugs and can result in a difficult transtition to buprenorphine.
Purpose/hypothesis: A transition from high potency opioids to buprenorphine is challenging and can cause discomfort or withdrawal in patients.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!