We describe a case of comedonal acne in a post-menopausal female treated with a novel tretinoin lotion 0.05%. The patient also had some actinic keratoses, which are hyperkeratotic, scaly lesions caused by prolonged exposure to ultraviolet radiation. These lesions have the ability to progress into squamous cell carcinoma. Actinic keratoses can occur in patients as young as 20 years, but are more common in patients aged 50 years and older. Topical retinoids are recommended as monotherapy in comedonal acne but despite their documented clinical efficacy are underutilized due to concerns about cutaneous tolerability. Topical tretinoin is currently not recommended as first-line therapy in the treatment of actinic keratosis as its efficacy is not comparable to that of other modalities. In this patient, a novel tretinoin lotion 0.05% resulted in rapid in and sustained improvement of acne. The investigator also observed improvement in actinic keratoses and photodamage. If these results can be confirmed in a larger patient population this may be an attractive area of investigation for the treatment of patients with adult acne and photodamaged skin.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7278291 | PMC |
| http://dx.doi.org/10.1177/2050313X20929798 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Topical Treatments for Melasma and Post-inflammatory Hyperpigmentation.
J Drugs Dermatol
November 2023
Article Synopsis
- * While topical hydroquinone remains the gold-standard treatment for these conditions, it poses safety issues for extended use, and over-the-counter products often lack adequate efficacy data.
- * Recent studies show that topical retinoids, especially tazarotene, offer a promising alternative with good efficacy and tolerability for managing melasma and PIH over a 24-week period.
Molluscum Contagiosum in HIV Patient Treated with 20% Topical Glycolic Acid After Resistance with Topical Tretinoin.
Clin Cosmet Investig Dermatol
September 2023
Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran - Dr. Hasan Sadikin General Hospital, Bandung, West Java, Indonesia.
Article Synopsis
- Molluscum contagiosum (MC) is a benign skin infection caused by the Molluscum contagiosum virus, with increasing incidence in HIV patients (5-8%) and no standard treatment.
- In this case, an HIV patient with MC was treated with 20% topical glycolic acid after failing other treatments, showing significant skin improvement by week 6.
- This therapy was effective with minimal side effects, including itching and hyperpigmentation, making it a safe option for MC treatment.
Pathogenesis-directed treatment of linear porokeratosis with topical cholesterol-lovastatin.
Pediatr Dermatol
March 2024
Department of Dermatology, Mayo Clinic, Rochester, Minnesota, USA.
A 2-year-old boy presented with an extensive, asymptomatic, photosensitive eruption refractory to topical steroids and tretinoin; examination and biopsies were consistent with generalized linear porokeratosis involving the face, limbs, and trunk. Treatment with topical cholesterol-lovastatin was initiated, and it successfully improved early erythematous lesions. Whole exome sequencing that targeted mevalonate pathway genes crucial in cholesterol synthesis later revealed a pathogenic, paternally inherited, porokeratosis-associated MVD, c.
View Article and Find Full Text PDFBackground: Photoaging due to cumulative lifetime ultraviolet light exposure is the greatest contributing factor to facial aging. With the continued growth of the population of individuals aged ≥65 years and over, demand for safe and effective photoaging treatments will likely increase.
Methods: This qualitative review provides an overview of efficacy and safety of over-the-counter (OTC) and prescription topical treatments for photoaging, including recent data from an investigator-initiated trial of the topical retinoid tazarotene.
Improvements in acne and skin oiliness with tazarotene 0.045% lotion in patients with oily skin.
J Dermatolog Treat
December 2023
Ortho Dermatologics, Division of Bausch Health US, LLC, Ortho Dermatologics, Bridgewater, NJ, USA.
Background: Excessive sebum production is a factor in acne development. Tazarotene 0.045% lotion has demonstrated reductions in acne lesions and acne-induced sequelae.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!