AI Article Synopsis
- Statins are commonly prescribed to lower the risk of cardiovascular disease (CVD), but research indicates they may increase the likelihood of herpes zoster (HZ), which is linked to a higher risk of CVD.
- A study examined over 275,000 individuals in South Korea, finding that statin users generally faced lower risks of CVD events like stroke and myocardial infarction compared to non-users.
- However, about 11.6% of the protective effect of statins against CVD was reduced due to the occurrence of HZ among statin users, particularly affecting those under 60 years of age.
Article Abstract
Background/aims: Although statins are widely used to reduce the risk of cardiovascular disease (CVD) including stroke and myocardial infarction (MI), it is reported that statin use increases the incidence of herpes zoster (HZ) that is associated with increased risk of CVD. So, we evaluated the mediation effect of HZ caused by statin use on CVD.
Methods: We analyzed a prospective cohort from the National Health Insurance Service-database of South Korea. All individuals received a medical check-up and were followed-up from 2002 to 2013.
Results: A total of 275,382 individuals > 40 years old were followed up for 11 years from 2003. Of these, 11,415 people (4%) were classified as statin users and 263,967 (96%) as non-statin users. Those who used statins had significantly lower risks of cardiovascular events, stroke, and MI compared with non-statin users; the adjusted hazard ratios in the multivariate analysis were 0.90 (95% confidence interval [CI], 0.82 to 0.98), 0.88 (95% CI, 0.80 to 0.98), and 0.91 (95% CI, 0.79 to 1.07), respectively. When we calculated the mediating effect of cardiovascular events by statin use through HZ, 11.6% of the total beneficial effect of cardiovascular events by statin use was mitigated through the occurrence of HZ caused by statin use. This mediating effect was higher in the younger age group (< 60 years).
Conclusion: This study showed that statin use reduced CVD by 10%, but the protective effect of statin use against CVD was mitigated by approximately 10% through the development of HZ caused by statin use.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7487315 | PMC |
| http://dx.doi.org/10.3904/kjim.2019.020 | DOI Listing |
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