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Temperature Regulates Astroglia Morphogenesis Through Thermosensory Circuitry in Caenorhabditis elegans.
Glia
January 2025
State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science and Department of Neurosurgery, Zhongshan Hospital, Fudan University, Shanghai, P. R. China.
Astrocytes are the most abundant type of macroglia in the brain and play crucial roles in regulating neural development and functions. The diverse functions of astrocytes are largely determined by their morphology, which is regulated by genetic and environmental factors. However, whether and how the astrocyte morphology is affected by temperature remains largely unknown.
View Article and Find Full Text PDFFunctional implications of NHR-210 enrichment in C. elegans cephalic sheath glia: insights into metabolic and mitochondrial disruptions in Parkinson's disease models.
Cell Mol Life Sci
May 2024
Division of Neuroscience and Ageing Biology, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, 226031, India.
Glial cells constitute nearly half of the mammalian nervous system's cellular composition. The glia in C. elegans perform majority of tasks comparable to those conducted by their mammalian equivalents.
View Article and Find Full Text PDFAge-progressive interplay of HSP-proteostasis, ECM-cell junctions and biomechanics ensures C. elegans astroglial architecture.
Nat Commun
April 2024
Developmental Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.
Tissue integrity is sensitive to temperature, tension, age, and is sustained throughout life by adaptive cell-autonomous or extrinsic mechanisms. Safeguarding the remarkably-complex architectures of neurons and glia ensures age-dependent integrity of functional circuits. Here, we report mechanisms sustaining the integrity of C.
View Article and Find Full Text PDFCEPsh glia development is not required for general AWC identity or AWC asymmetry.
MicroPubl Biol
September 2022
Department of Biological Sciences, University of Illinois at Chicago, IL, USA.
The VAB-3/Pax6 homeodomain protein was previously shown to play a role in both the development of cephalic sheath (CEPsh) glia and asymmetric differentiation of AWC olfactory neuron subtypes AWC /AWC . Here we show that is not required for the specification of general AWC identity. We also show that some mutant alleles with defective CEPsh glia development displayed wild-type AWC asymmetry.
View Article and Find Full Text PDFRegulation of Gliogenesis by /Atoh1 in .
G3 (Bethesda)
September 2020
Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710
The regulation of gliogenesis is a fundamental process for nervous system development, as the appropriate glial number and identity is required for a functional nervous system. To investigate the molecular mechanisms involved in gliogenesis, we used as a model and identified the function of the proneural gene Atoh1 in gliogenesis. We found that functions during embryonic development to negatively regulate the number of AMsh glia.
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