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| http://dx.doi.org/10.17912/micropub.biology.000118 | DOI Listing |
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Mapping genomic regions for reproductive stage drought tolerance in rice from exotic landrace-derived population.
Front Plant Sci
January 2025
South Asia Hub, International Rice Research Institute (IRRI), International Crops Institute for the Semi-Arid Tropics (ICRISAT) Campus, Hyderabad, Telangana, India.
In the rapid climate change scenario and subsequent rainfall patterns, drought has emerged as a bottleneck for crop production across crops, especially in rainfed rice. Drought significantly affects the development and production of most modern rice cultivars. Thus, recent breeding efforts have aimed to integrate drought tolerance traits in existing rice varieties through conventional and molecular approaches.
View Article and Find Full Text PDFUtilizing sc-linker to integrate single-cell RNA sequencing and human genetics to identify cell types and driver genes associated with non-small cell lung cancer.
BMC Cancer
January 2025
Department of Radiation Oncology, Xiamen Cancer Center, Xiamen Key Laboratory of Radiation Oncology, School of Medicine, The First Affiliated Hospital of Xiamen University, Xiamen University, Xiamen, China.
Background: Genome-wide association studies (GWAS) provide a powerful method for identifying the loci and genes that contribute to disease. However, in many cases, the specific cell types and states that confer disease risk through these genes remain unknown. Determining this relationship is crucial for identifying pathogenic processes and developing therapeutic strategies.
View Article and Find Full Text PDFOptimization of genome editing by CRISPR ribonucleoprotein for high efficiency of germline transmission of Sox9 in zebrafish.
N Biotechnol
January 2025
Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, 430072, China. Electronic address:
Primordial germ cells (PGCs) are the first germline stem cells to emerge during early embryonic development and are essential for the propagation and survival of species. Genome editing creates mutagenesis possibilities in vivo, but the generation of precise mutations in PGCs is still challenging. Here, we report an optimized approach for highly efficient genome editing via introducing biallelic variations in early embryos in zebrafish.
View Article and Find Full Text PDFMassively parallel reporter assay investigates shared genetic variants of eight psychiatric disorders.
Cell
January 2025
Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address:
A meta-genome-wide association study across eight psychiatric disorders has highlighted the genetic architecture of pleiotropy in major psychiatric disorders. However, mechanisms underlying pleiotropic effects of the associated variants remain to be explored. We conducted a massively parallel reporter assay to decode the regulatory logic of variants with pleiotropic and disorder-specific effects.
View Article and Find Full Text PDFGenetic dissection of foxtail millet bristles using combined QTL mapping and RNA-seq.
Theor Appl Genet
January 2025
College of Agriculture, State Key Laboratory of Crop Stress Biology in Arid Areas, Northwest A&F University, Yangling, 712100, China.
QTL mapping of two RIL populations in multiple environments revealed a consistent QTL for bristle length, and combined with RNA-seq, a potential candidate gene influencing bristle length was identified. Foxtail millet bristles play a vital role in increasing yields and preventing bird damage. However, there is currently limited research on the molecular regulatory mechanisms underlying foxtail millet bristle formation, which constrains the genetic improvement and breeding of new foxtail millet varieties.
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