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| http://dx.doi.org/10.17912/micropub.biology.000102 | DOI Listing |
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Polymyxin B induces pigmentation by upregulating ATG2A-ERK/CREB-MITF-PMEL17 signaling axis.
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Key Laboratory of Biotechnology of Antibiotics, the National Health Commission (NHC), Beijing Key Laboratory of Antimicrobial Agents, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. Electronic address:
Polymyxin B serves as the last line of defense in treating multidrug-resistant Gram-negative bacterial infections. However, its distinctive side effect of hyperpigmentation significantly impacts patients' psychological well-being and treatment adherence. Currently, the underlying mechanism of polymyxin B-induced pigmentation remains to be incompletely investigated.
View Article and Find Full Text PDFAging and autophagic phenotypic changes in bone marrow mesenchymal stem cells in glucocorticoid-induced osteonecrosis.
Int Immunopharmacol
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Department of Bone and Joint Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China. Electronic address:
Background: Glucocorticoid (GC) overuse is the main cause of osteonecrosis of the femoral head (ONFH). The dysfunction of bone marrow mesenchymal stem cells (BMSCs) plays an important role in ONFH pathogenesis. Physiological concentrations of GCs can induce the osteogenic differentiation of BMSCs; however, intervention with high concentrations of GC may lead to changes in aging and autophagy in certain cell types.
View Article and Find Full Text PDFSpectral and color temperature dependence of LED exposure on retinal damage and the protective effects of neohesperidin.
J Photochem Photobiol B
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Department of Ophthalmology and Optometry, Fujian Medical University, Fuzhou, China. Electronic address:
Purpose: To investigate the effects of LEDs with different spectra and correlated color temperatures on the retina, as well as the protective role of neohesperidin(NHP).
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Native potential probiotics and postbiotics improve the gut-kidney axis by the modulation of autophagy signaling pathway.
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Department of Bacteriology, Pasteur Institute of Iran, Tehran, Iran.
The gut-kidney axis is the bidirectional relationship between the gut microbiota and the kidney function. Chronic inflammatory responses can impair kidney function and probiotics and postbiotics agents can have positive effects on gut health and kidney function by modulating inflammation through affecting autophagy signaling pathway. The aim of the current study was to evaluate the properties of our probiotic and postbiotics to improve kidney health by focusing the autophagy signaling pathway.
View Article and Find Full Text PDFEffect of spermidine on cuproptosis in follicular granulosa cells.
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State Key Laboratory of Swine and Poultry Breeding Industry, Key Laboratory of Agricultural Bioinformatics, Ministry of Education, Key Laboratory of Livestock and Poultry Multi-omics, Ministry of Agriculture and Rural Affairs, College of Animal and Technology, Sichuan Agricultural University, Chengdu, China.
1. A study was conducted to investigate the effect of spermidine on cuproptosis in granulosa cells of goose ovarian follicles. Granulosa cells from F2-F5 grade follicles of Sichuan white geese were isolated and cultured.
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