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Postmarketing Surveillance of Full Spectrum Hemp Extract CBD Products: Reported Adverse Events and Serious Adverse Events.
Drugs Real World Outcomes
December 2024
Massachusetts College of Pharmacy and Health Science, Boston, MA, USA.
Background: There is a growing interest in products featuring hemp extracts and a demand for more data regarding their safety. To date, there is a paucity of published data on the safety of these products.
Methods: A retrospective analysis of postmarketing surveillance data collected in the United States on full spectrum hemp extract (FSHE) products manufactured by Charlotte's Web (CW) was conducted over an 18-month period (January 2019 to July 2020).
Total cannabidiol (CBD) concentrations and yields from traditional extraction methods: Percolation vs. maceration.
Front Pharmacol
October 2022
Health, Education & Research, Driggs, ID, United States.
Medicinal plants have been valued for many generations due to their biosynthetic advantages generating pharmacologically active molecules. This is especially the case when it comes to cannabinoids from Cannabis. In these experiments we mimicked typical herbal home extractions and measured the yield of total decarboxylated CBD ("total CBD") from percolations and macerations done at the common duration of 2 weeks in duplicate independent extractions.
View Article and Find Full Text PDFPolyphenolic promiscuity, inflammation-coupled selectivity: Whether PAINs filters mask an antiviral asset.
Front Pharmacol
October 2022
Massachusetts College of Pharmacy and Health Sciences, Boston, MA, United States.
The Covid-19 pandemic has elicited much laboratory and clinical research attention on vaccines, mAbs, and certain small-molecule antivirals against SARS-CoV-2 infection. By contrast, there has been comparatively little attention on plant-derived compounds, especially those that are understood to be safely ingested at common doses and are frequently consumed in the diet in herbs, spices, fruits and vegetables. Examining plant secondary metabolites, we review recent elucidations into the pharmacological activity of flavonoids and other polyphenolic compounds and also survey their putative frequent-hitter behavior.
View Article and Find Full Text PDFClinical utility of curcumin extract.
Altern Ther Health Med
July 2013
Department of Family Medicine, University of North Carolina, Chapel Hill, North Carolina, USA.
Turmeric root has been used medicinally in China and India for thousands of years. The active components are thought to be the curcuminoids, primarily curcumin, which is commonly available worldwide as a standardized extract. This article reviews the pharmacology of curcuminoids, their use and efficacy, potential adverse effects, and dosage and standardization.
View Article and Find Full Text PDFThe traditional medicine Spilanthes acmella, and the alkylamides spilanthol and undeca-2E-ene-8,10-diynoic acid isobutylamide, demonstrate in vitro and in vivo antimalarial activity.
Phytother Res
July 2011
Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, 251 Bayview Blvd, Baltimore, MD 21224, USA.
Spilanthes spp. are used as traditional herbal medicines in Africa and India to treat malaria. Yet, to date, there are no data on the active constituents or the most effective extraction methods for this indication.
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