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Pseudoangiomatous stromal hyperplasia (PASH) is a benign but rare mesenchymal proliferation of the mammary stroma, characterized by pseudovascular spaces within a hyperplastic matrix. PASH can be classified as either non-tumor-forming or tumor-forming. The non-tumor-forming type is an infiltrative and clinically undetectable mass, incidentally found in approximately a quarter of breast biopsies.

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Phyllodes tumor is a rare and particular type of breast tumor with features of stromal hyperplasia and malignant potential. The present case is an unusual presentation of a phyllodes tumor with pseudoangiomatous stromal hyperplasia (PASH) which forms an essential part of benign breast disease but is not frequently described in association with phyllodes tumor. A 36-year-old female patient was referred to the hospital with a large breast mass considered to be a benign growth.

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Mesenchymal and spindle cell tumors of the breast represent a broad and heterogeneous group of lesions that may be sampled on core needle biopsy or surgical excision. Mesenchymal lesions unique to the breast are those that derive from the specialized breast myofibroblast, such as mammary myofibroblastoma and pseudoangiomatous stromal hyperplasia. However, any mesenchymal lesion arising in extramammary soft tissue may also arise in the breast, including fibroblastic, peripheral nerve sheath, adipocytic, and vascular lesions.

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Pseudoangiomatous stromal hyperplasia (PASH) of the breast: A case series.

Updates Surg

December 2024

Breast Surgery Division, Istituto Nazionale Tumori-IRCCS-Fondazione G. Pascale, Naples, Italy.

Pseudoangiomatous stromal hyperplasia (PASH) is a benign mesenchymal proliferative lesion of the breast. In 2005, only 109 cases have been reported since its initial description in 1986 by Vuitch et al. when it presented in one patient as a palpable breast mass.

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Diffuse unilateral MRI breast entities.

Clin Imaging

November 2024

Department of Radiology, Penn State Health, Hershey Medical Center, 30 Hope Drive, EC 008, Breast Center, Hershey, PA 17033, United States of America. Electronic address:

Article Synopsis
  • The text discusses various benign and malignant breast conditions that can show similar diffuse unilateral findings on MRI, which can complicate diagnosis.
  • It categorizes these findings into three main types: asymmetric diffuse masses or non-mass enhancement, diffuse unilateral skin thickening, and diffuse asymmetric background enhancement.
  • The review emphasizes that while clinical correlation is essential, biopsy is often needed for a definitive diagnosis, and outlines specific MRI characteristics that help differentiate between conditions, such as morphology and enhancement kinetics.
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