Introduction: Urolithiasis is a health problem that is increasing all over the world as in Algeria, but with scarce local data.
Aim: To determine, for the first time, the epidemiological characteristics of urolithiasis in western Algeria.
Methods: We determined the socio-demographic parameters, the clinical data, and those related to stones of 1104 adult stone formers (2012-2019).
Results: We confirmed the higher prevalence of urolithiasis among males (sex-ratio=1.9). Stone formers were overweight or obese in 57.2% of cases, 56.7% were living in urban areas and 53.1% had a poor educational level. The rate of consanguinity was 25% and 33.9% had a family history. Stone recurrence was 51.1% and 89% of stones were located in the upper urinary tract. Spontaneous expulsion was the most frequent way of elimination (51.9%), open surgery was used in 19.7%, while 15.5% resorted to endourology or extracorporeal shock wave lithotripsy. The predominant component of stones was calcium oxalate (75%), followed by calcium phosphates (8.9%) and uric acid (10.2%). Struvite (urinary infection indices) was in 3.4% of stones but detected in 16.9% and cystine was found in 1%. Males had a higher educational level, a higher consanguinity rate, and more recurrences than females.
Conclusion: The epidemiologic profile coming out of this study is close to those described in Maghreb and in industrialized countries. Our data showed that there is an improvement of the socio-economical level, but modern techniques of stone removal should be used more, as well as change in lifestyle.
Download full-text PDF |
Source |
---|
Medicine (Baltimore)
November 2024
Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Rationale: Urinary calculi are hard mineral deposits that typically require medication or surgery, such as lithotripsy. This case report presents traditional Chinese exercises (TCEs) as a potential alternative for stone expulsion.
Patient Concerns: A 41-year-old male with no history of urinary tract stones, experienced sudden severe lower back and abdominal pain accompanied by nausea and vomiting.
Urolithiasis
December 2024
Department of Nephro-urology, Nagoya City University Graduate School of Medical Sciences, 1, Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Japan.
The early stages of kidney crystal formation involve inflammation and hypoxia-induced cell injury; however, the role of the hypoxic response in kidney crystal formation remains unclear. This study investigated the effects of a prolyl hydroxylase domain inhibitor (roxadustat) on renal calcium oxalate (CaOx) crystal formation through in vitro and in vivo approaches. In the in vitro experiment, murine renal tubular cells (RTCs) were exposed to varying roxadustat concentrations and CaOx crystals.
View Article and Find Full Text PDFMil Med Res
December 2024
Department of Urology, University College Hospital of London, London, NW1 2BU, UK.
Urolithiasis
December 2024
Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
The commencement of kidney stone formation involves a crucial initial phase characterized by injury to renal tubular cells caused by calcium oxalate (CaOx). Dioscin (Dio) has been acknowledged for its potent anti-inflammation and anti-apoptotic properties; nevertheless, the impact and underlying Investigation into the molecular basis underlying the action of Dioscin in mitigating inflammation and apoptotic induced by exposure to calcium oxalate crystals in renal tissues remain unexplored. To comprehend the precise mechanism of Dioscin in the treatment of crystalline nephropathy, we conducted experiments utilizing a murine model of CaOx crystal deposition, induced by intraperitoneal administration of glyoxylate.
View Article and Find Full Text PDFNat Commun
December 2024
Department of Cardiovascular and Metabolic Sciences, Cleveland Clinic, Cleveland, OH, USA.
Clinical studies of the urinary tract microbiome, termed urobiome, suggest a direct, antibiotic-dependent, impact of the urobiome on kidney physiology. However, evidence for kidney bacteria comes from indirect sources or infected tissue. Further, it is unclear how antibiotics impact kidney bacteria.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!