Highly enantioselective Friedel-Crafts alkylation of pyrroles with 2-enoyl-pyridine -oxides in water/chloroform (10:1) was developed under catalysis of Lewis acid. The Friedel-Crafts alkylation products can be obtained in high yields and excellent enantioselectivities. Moreover, several control experiments were carried out to study the reaction mechanism.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271029 | PMC |
| http://dx.doi.org/10.1021/acsomega.9b04115 | DOI Listing |
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