Purpureocillium lilacinum is a rare but emerging pathogen in immunocompromised patients that primarily infects the skin and subcutaneous tissue. We present a novel case of Purpureocillium lilacinum infection in a patient with pyoderma gangrenosum who was successfully treated with isavuconazonium, followed by a literature review of 13 total cases of infection with Purpureocillium lilacinum gathered from a review of the PubMed database. Previous reports have utilized voriconazole, an antifungal with significant toxic side effects. Our case highlights the importance of culture and biopsy in patients with pyoderma gangrenosum who are unresponsive to standard treatment irrespective of pathergy risk.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286926 | PMC |
| http://dx.doi.org/10.1016/j.mmcr.2020.05.006 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Leucinostatins target Plasmodium mitochondria to block malaria transmission.
Parasit Vectors
December 2024
Department of Biological Sciences, Florida International University, 11200 SW 8th St, Miami, FL, 33199, USA.
Background: Malaria remains a critical disease. Leucinostatins from the fungus Purpureocillium lilacinum inhibited the transmission of Plasmodium falciparum to mosquitoes via contact.
Methods: Here, we modified the leucinostatin B (LB) C-terminus to make derivatives and examined their inhibition against malaria transmission to mosquitoes.
Identification and growth-promoting effect of Paecilomyces lilacinus a biocontrol fungi for walnut rot disease.
PLoS One
December 2024
Tarim University/Key Laboratory of Integrated Pest Management (IPM) of Xinjiang Production and Construction Corps in Southern Xinjiang, College of Agriculture, Alar, China.
Cytospora chrysosperma is the primary pathogen responsible for walnut rot disease, affecting a wide variety of hosts. Currently, chemical agents, particularly agricultural Fungicides, are commonly utilized for the prevention and management of walnut rot. However, this practice has led to the development of drug-resistant pathogens, complicating disease control efforts.
View Article and Find Full Text PDFExtracellular Biosynthesis, Characterization and Antimicrobial Activity of Silver Nanoparticles Synthesized by Filamentous Fungi.
J Fungi (Basel)
November 2024
Biotechnology and Bioanalysis Department, National Institute for Research & Development in Chemistry and Petrochemistry-ICECHIM, 202 Independentei Spl., 060021 Bucharest, Romania.
The green synthesis of metal nanoparticles has received substantial attention due to their applications in various domains. The aim of the study was to obtain silver nanoparticles (AgNPs) by green synthesis with filamentous fungi, such as , , and . Fungal species were grown on nutrient media and aqueous mycelium extracts were used to reduce Ag to Ag (0).
View Article and Find Full Text PDFRevealing the metabolic potential and environmental adaptation of nematophagous fungus, , derived from hadal sediment.
Front Microbiol
November 2024
Shanghai Engineering Research Center of Hadal Science and Technology, College of Oceanography and Ecological Science, Shanghai Ocean University, Shanghai, China.
Article Synopsis
- Fungi in deep-sea habitats, like the Mariana Trench, possess unique metabolic capabilities that enable them to thrive under extreme conditions, but research on their activities is limited.
- Researchers studied a specific filamentous fungus, FDZ8Y1, demonstrating its tolerance to high hydrostatic pressure (HHP) and its potential for antibacterial, antitumor, and nematicidal activities.
- Whole-genome sequencing and transcriptomic analysis revealed that FDZ8Y1 activates various metabolic pathways to adapt to HHP, highlighting its potential for discovering novel natural products and understanding fungal adaptation in extreme environments.
Chemical Constituents of the Deep-sea Derived Fungus Purpureocillium lilacinum XIA-9.
Chem Biodivers
November 2024
Key Laboratory of Marine Genetic Resources, Third Institute of Oceanography, Ministry of Natural Resources, 184 Daxue Road, Xiamen, 361005, China.
Two new sphingosine derivatives (1 and 2), two new vicinal diol analogs (3 and 4), one new diol analog (5), one new fatty acid (9), together with 19 known compounds (6-8, 10-24), were isolated from Purpureocillium lilacinum XIA-9. Their structures were determined by detailed analysis of the 1D and 2D NMR, HRESIMS, and optical rotatory data. Fusarubin 3-methyl ether (17) exhibited potent inhibition on RSL3 induced ferroptosis with the EC value of 0.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!