Background And Aim: Many recent studies have shown a direct relationship between the decrease in the expression of and with the incidence and progression of prostate cancer. Moreover, the expression level of these genes is greatly affected by epigenetic factors and their methylation pattern. Given the prevalence of prostate cancer and the importance of choosing the best method to inhibit the progression of the disease and provide specific treatment, it is important to evaluate the effect of hormone therapy on the expression of effective prostate cancer genes and epigenetic markers.
Patients And Methods: In this case-control study, 35 prostate cancer samples were examined before and after hormone therapy. Following the blood sampling, RNA extraction, and cDNA synthesis, the expression of , and was assessed by real-time PCR.
Results: The results analysis showed that the expression of , and was significantly increased, was significantly decreased ( value<0.05) and expression did not change significantly ( value=0.19) after hormone therapy.
Discussion: Significant changes in the expression of and in the studied samples indicate that these genes are susceptible targets for cancer hormone therapy in Iranian men like in the other populations. Evaluation of gene activity in a larger population of patients may support these findings.
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| http://dx.doi.org/10.2147/CMAR.S251297 | DOI Listing |
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