AI Article Synopsis
- - This study examines the impact of body fat, particularly visceral fat, on the prognosis of patients with metastatic colorectal cancer (MCRC) and finds that higher visceral fat levels are linked to poorer outcomes.
- - A total of 71 MCRC patients were analyzed; a significant number had a body mass index (BMI) above 25, and a specific cut-off value of visceral fat (44) was established as a threshold for prognosis.
- - Key findings indicate that visceral fat levels greater than 44 cm² are associated with increased risk of death, while surgical interventions like primary tumor resection and metastasectomy also play a critical role in overall survival.
Article Abstract
Background: Body composition, has been established as a risk factor for colorectal cancer diagnosis and disease progression. Aim of this study was to investigate the prognostic role of adiposity, especially visceral fat (VAT), in patients (pts) with metastatic colorectal cancer (MCRC).
Material And Methods: A retrospective cohort of 71 MCRC pts treated between 2013 and 2017 was evaluated. VAT was measured as cross-sectional (cm) area at the L3 level divided by the square of the height (m). A ROC analysis was performed to define a prognostic threshold according to VAT.
Results: Before first-line therapy start, 40 pts (56%) had a body mass index (BMI) > 25 kg/m. The obtained cut-off value for VAT was 44. Median OS was 30.97 months. At univariate analysis, primary tumor resection (HR 0.40, p = 0.029), VAT>44 (HR 2.85, p = 0.011) and metastasectomy (HR 0.22, p = 0.005) were significantly associated with OS. By multivariate analysis, VAT>44 (HR 2.6; p = 0.020) and metastasectomy were still significantly associated with OS.
Conclusion: This exploratory study suggests a prognostic role for VAT in MCRC pts, with higher VAT values predicting worse outcome.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.clnu.2020.05.019 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!