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Major Depressive Disorder and Driving Behavior Among Older Adults.
JAMA Netw Open
December 2024
Department of Psychiatry, Washington University in St Louis, St Louis, Missouri.
Importance: Depression and antidepressant use are independently associated with crash risk among older drivers. However, it is unclear what factors impact daily driving that increase safety risk for drivers with depression.
Objective: To examine differences in naturalistic driving behavior and safety between older adults with and without major depressive disorder (MDD).
Biomarkers.
Alzheimers Dement
December 2024
Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Background: Older vervet monkeys are an excellent model for studying age-associated Aβ deposition; however, they have high proportions of low-affinity Aβ sites compared to human brains. Commonly used Aβ PET radiotracers are most useful in detecting high affinity Aβ fibrils. Measuring real-time levels of low affinity Aβ fibrils through PET provides critical information of early AD progression.
View Article and Find Full Text PDFBiomarkers.
Alzheimers Dement
December 2024
Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Background: Little is known about how plasma Alzheimer's disease (AD) biomarkers relate to neuroimaging biomarkers of cerebral small vessel disease (cSVD) in the context of neurodegeneration and AD pathology in late life.
Method: This cross-sectional study included 251 Multi-Ethnic Study of Atherosclerosis (MESA) Exam 6 participants with plasma AD biomarkers (Aβ42/Aβ40, GFAP, NfL, p-tau181, p-tau217, p-tau231; Quanterix SIMOA), MRI (neurodegeneration and cSVD), PiB (amyloid) PET, and UDSv3-based adjudicated cognitive status (69% cognitively normal, 27% MCI, 4% probable dementia) data at the Wake Forest site. Multivariable models examined relationships among cognitive status, plasma, and neuroimaging biomarkers (covariates: age, education, race, gender, smoking status, kidney function [eGFR], APOE-ε4, BMI; significance at p<.
Biomarkers.
Alzheimers Dement
December 2024
Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Background: Uniform manifold approximation and projection (UMAP) is a technique for dimension reduction and visualization of high-dimensional (HD) data. Here, we apply UMAP to represent in two dimensions, data from members of the Wake Forest School of Medicine Alzheimer's Disease Research Center (WFUSM-ADRC) clinical cohort.
Methods: We examined baseline data from 542 WFUSM-ADRC participants with mean age 70.
Biomarkers.
Alzheimers Dement
December 2024
Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Background: Early autonomic function changes in Alzheimer's disease (AD) may represent a biomarker for early affective changes in prodromal disease. We report preliminary differences in metrics of heart rate variability (HRV) before and during routine cognitive testing.
Method: We enrolled 50 participants from the Wake Forest Alzheimer's Disease Research Center to wear continuous ECG devices during their visit to assess time and frequency domain based metrics of HRV over 5 minutes at rest and during cognitive testing.
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