Although exposure to ambient air pollution has been linked to mental health problems, little is known about its potential effects on youth. This study investigates the association between short-term exposure to air pollutants and emergency department (ED) visits for mental health disorders. The National Ambulatory Care Reporting System database was used to retrieve ED visits for young individuals aged 8-24 years in Toronto, Canada. Daily average concentrations of nitrogen dioxide (NO), fine particulate matter (PM), and daily maximum 8 h ozone (O) were calculated using measurement data from seven fixed stations. A case-crossover (CC) design was implemented to estimate the associations between ED visits and air pollution concentrations. Mental health ED visits were identified using International Classification of Diseases 10th Revision (ICD-10) codes, with seven categories considered. Models incorporating air pollutants and ambient temperature (with lags of 0-5 days) using a time-stratified CC technique were applied. Multivariable regression was performed by sex, three age groups, and seven types of mental health disorders to calculate relative risk (RR). The RRs were reported for one interquartile range (IQR) change in the air pollutant concentrations. Between April 2004 and December 2015 (4292 days), there were 83,985 ED visits for mental-health related problems in the target population. Several exposures to air pollutants were shown to have associations with ED visits for mental health including same day exposure to fine particulate matter (IQR = 6.03 μg/m, RR = 1.01 (95% confidence interval: 1.00-1.02), RR = 1.02 (1.00-1.03)) for all and female-only patients, respectively. One-day lagged exposure was also associated with ED visits for PM (RR = 1.02 (1.01-1.03)), for nitrogen dioxide (IQR = 9.1 ppb, RR = 1.02 (1.00-1.04)), and ozone (IQR = 16.0 ppb, RR = 1.06 (1.01-1.10)) for males. In this study, urban air pollution concentration-mainly fine particulate matter and nitrogen dioxide-is associated with an increased risk for ED visits for adolescents and young adults with diagnosed mental health disorders.
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http://dx.doi.org/10.3390/ijerph17124190 | DOI Listing |
J Nephrol
January 2025
School of Life and Medical Sciences, University of Hertfordshire, College Lane Campus, Hatfield, UK.
Integr Cancer Ther
January 2025
Guang 'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Braz J Psychiatry
January 2025
Graduate Program in Psychiatry and Behavioral Sciences, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil. Universidade de São Paulo, São Paulo, SP, Brazil.
Mol Ther
January 2025
School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China; Chinese Institute for Brain Research, Beijing 102206, China. Electronic address:
The development of efficient and targeted methods for delivering DNA in vivo has long been a major focus of research. In this study, we introduce a gene Delivery approach Admitted by small Metabolites, named gDAM, for the efficient and targeted delivery of naked DNA into astrocytes in the adult brains of mice. gDAM utilizes a straightforward combination of DNA and small metabolites, including glycine, L-proline, L-serine, L-histidine, D-alanine, Gly-Gly, and Gly-Gly-Gly, to achieve astrocyte-specific delivery of naked DNA, resulting in transient and robust gene expression in these cells.
View Article and Find Full Text PDFBMC Psychol
January 2025
School of Education, College of Arts & Science, Universiti Utara Malaysia, Sintok, Malaysia.
Background: In clinical practice, creative arts therapy is frequently utilized for the treatment of traumatized adults, with reports of favorable outcomes. However, the effectiveness of this intervention in post-traumatic stress disorder (PTSD) treatment has not yet been definitively established through meta-analysis. In this meta-analysis, we aim to assess the effectiveness of creative arts therapy in the management of PTSD.
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