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A safe-enhanced fully closed-loop artificial pancreas controller based on deep reinforcement learning.
PLoS One
January 2025
Institute of Visual Informatics, The National University of Malaysia (UKM), Bangi, Malaysia.
Patients with type 1 diabetes and their physicians have long desired a fully closed-loop artificial pancreas (AP) system that can alleviate the burden of blood glucose regulation. Although deep reinforcement learning (DRL) methods theoretically enable adaptive insulin dosing control, they face numerous challenges, including safety and training efficiency, which have hindered their clinical application. This paper proposes a safe and efficient adaptive insulin delivery controller based on DRL.
View Article and Find Full Text PDFThe Era of Antibody Drug Conjugates in Lung Cancer: Trick or Threat?
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Department of Cancer Medicine, Gustave Roussy Cancer Campus, Villejuif, France.
Antibody Drug Conjugates (ADCs) are a novel class of therapeutics that structurally are composed by an antibody directed to a tumour epitope connected via a linker to a cytotoxic payload, and that have shown significant antitumor activity across a range of malignancies including lung cancer. In this article we review the pharmacology and design of ADCs, as well as we describe the results of different studies evaluating ADCs in lung cancer directed to several targets including HER2, HER3, TROP2, MET, CEACAM5 and DLL3, among others.
View Article and Find Full Text PDFAntiviral Effect of Melatonin on Caco-2 Cell Organoid Culture: Trick or Treat?
Int J Mol Sci
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Department of Pediatrics, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania.
Melatonin is a hormone naturally produced by the body that has recently been found to have antiviral properties. However, its antiviral mechanisms are not entirely understood. Using Caco-2 cells, we developed a gastrointestinal organoid model to investigate the impact of melatonin on cellular organoid culture response to Poly I:C-induced viral inflammation in the gastrointestinal tract.
View Article and Find Full Text PDFExploiting protein domain modularity to enable synthetic control of engineered cells.
Curr Opin Biomed Eng
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School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta GA 303332, USA.
The ability to precisely control cellular function in response to external stimuli can enhance the function and safety of cell therapies. In this review, we will detail how the modularity of protein domains has been exploited for cellular control applications, specifically through design of multifunctional synthetic constructs and controllable split moieties. These advances, which build on techniques developed by biologists, protein chemists and drug developers, harness natural evolutionary tendencies of protein domain fusion and fission.
View Article and Find Full Text PDFCannabis use disorder: from neurobiology to treatment.
J Clin Invest
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Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada.
Cannabis has been legalized for medical and recreational purposes in multiple countries. A large number of people are using cannabis and some will develop cannabis use disorder (CUD). There is a growing recognition that CUD requires specific interventions.
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