Offer some recommendations or guidelines during the evolution of the COVID-19 pandemic in terms of diagnosis, treatment and follow-upin the field of Reconstructive Urology. MATERIAL AND METHOD: The document is based on the evidence on SARS/Cov-2 and the authors' experience in managing COVID-19 in their institutions, including specialists from Andalusia, Madrid, Cantabria,the Valencian Community and Catalonia. A web and PubMed search was performed using "SARS-CoV-2", "COVID-19", "COVID-19 Urology", "COVID19 urology complications", "COVID-19 reconstructive surgery".A narrative review of the literature was carried out (5/17/2020) and after the nominal group technique modified due to the extraordinary restrictions, a first draft was made to unify criteria and reach a quick consensus. Finally, a definitive version was made, agreed by all the authors (5/22/2020). RESULTS: The authors defined the following surgical priorities for Urological Reconstructive Surgery: Emergency/Urgency (life-threatening or emergencies still in anormal situation), Elective Urgency/High priority (potentially dangerous pathology if postponed for more than 1month), Elective Surgery/Intermediate priority (pathology with little probability of being dangerous but it is recommended not to delay more than 6 months), Delayed surgery/Low priority (non-dangerous pathology if it is postponed for more than 6 months). According to this classification, the Working Group agreed on the distribution of the different surgical scenarios of Reconstructive Urology. In addition, consensus was reached on recommendations regarding the diagnosis and follow-up of pathology in the field of Reconstructive Urology. CONCLUSIONS: Tools should be implemented to facilitate the gathering of the medical visit and diagnostic tests. Redistribution of surgical procedures based on priority degrees is necessary during the pandemic and transition period. The use of telemedicine is essential forfollow-up, by computer, telephone or videoconference.
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ACS Nano
December 2024
Faculty of Materials Science, Shenzhen MSU-BIT University, Shenzhen 518100, P. R. China.
Protein hydrolysis targeted chimeras (PROTACs) represent a different therapeutic approach, particularly relevant for overcoming challenges associated with traditional small molecule inhibitors. These challenges include targeting difficult proteins that are often deemed "undruggable" and addressing issues of acquired resistance. PROTACs employ the body's own E3 ubiquitin ligases to induce the degradation of specific proteins of interest (POIs) through the ubiquitin-proteasome pathway.
View Article and Find Full Text PDFSci Rep
December 2024
College of Sports, Beihua University, Jilin, 132000, China.
In order to eliminate the impact of camera viewpoint factors and human skeleton differences on the action similarity evaluation and to address the issue of human action similarity evaluation under different viewpoints, a method based on deep metric learning is proposed in this article. The method trains an automatic encoder-decoder deep neural network model by means of a homemade synthetic dataset, which maps the 2D human skeletal key point sequence samples extracted from motion videos into three potential low-dimensional dense spaces. Action feature vectors independent of camera viewpoint and human skeleton structure are extracted in the low-dimensional dense spaces, and motion similarity metrics are performed based on these features, thereby effectively eliminating the effects of camera viewpoint and human skeleton size differences on motion similarity evaluation.
View Article and Find Full Text PDFSci Rep
December 2024
Univ. Grenoble Alpes, CEA, Inserm, IRIG, UA13 BGE, Biomics, Grenoble, 38000, France.
Xeroderma pigmentosum group C (XPC) is a versatile protein crucial for sensing DNA damage in the global genome nucleotide excision repair (GG-NER) pathway. This pathway is vital for mammalian cells, acting as their essential approach for repairing DNA lesions stemming from interactions with environmental factors, such as exposure to ultraviolet (UV) radiation from the sun. Loss-of-function mutations in the XPC gene confer a photosensitive phenotype in XP-C patients, resulting in the accumulation of unrepaired UV-induced DNA damage.
View Article and Find Full Text PDFCell Rep Methods
December 2024
Portrai, Inc., Dongsullagil, 78-18 Jongrogu, Seoul, Republic of Korea; Department of Nuclear Medicine, Seoul National University Hospital, 03080 Seoul, Republic of Korea; Department of Nuclear Medicine, Seoul National University College of Medicine, 03080 Seoul, Republic of Korea. Electronic address:
Spatially resolved transcriptomics (ST) has revolutionized the field of biology by providing a powerful tool for analyzing gene expression in situ. However, current ST methods, particularly barcode-based methods, have limitations in reconstructing high-resolution images from barcodes sparsely distributed in slides. Here, we present SuperST, an algorithm that enables the reconstruction of dense matrices (higher-resolution and non-zero-inflated matrices) from low-resolution ST libraries.
View Article and Find Full Text PDFJ Environ Radioact
December 2024
Research & Development Institute of Northwestern Polytechnical University in Shenzhen, Shenzhen, 518063, China. Electronic address:
Gamma-ray coded-aperture imaging technology has important applications in the fields of nuclear security, isolated source detection, and the decommissioning of nuclear facilities. However, artifacts can reduce the quality of reconstructed images and affect the identification of the intensity and location of radioactive sources. In this paper, a gamma-ray coded-aperture imaging method based on primitive and reversed coded functions (PRCF) was proposed to reduce imaging artifacts.
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