El nuevo coronavirus tipo 2 (SARS-CoV-2)del síndrome respiratorio agudo grave y la enfermedadque produce, enfermedad por coronavirus2019 (COVID-19) fueron descritos por primera vezen la ciudad China de Wuhan en Diciembre de2019 (1). En Marzo de 2020, la dispersión mundialde este nuevo patógeno, condujo a la declaraciónde pandemia por parte de la Organización Mundialde la Salud (OMS) (2).
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Selective treatment de-escalation in advanced prostate cancer: have we come full circle?
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Compelling evidence has solidified the notion of early treatment intensification in managing patients with metastatic hormone-sensitive prostate cancer (mHSPC). Landmark trials have provided Level 1 evidence for the survival benefits achieved by combining multiple agents. The efficacy of combined therapy relies not only on how treatment is intensified but also on how it is de-escalated.
View Article and Find Full Text PDFDeciphering the pathogen heterogeneity for precise diagnosis and personalized therapeutics of infections after kidney transplantation: insights from metagenomic next-generation sequencing.
Front Cell Infect Microbiol
November 2024
Department of Urology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Introduction: The aim of this study was to compare the detection performance of mNGS against that of conventional tests (CT) in patients suffering from infection after kidney transplantation.
Methods: A total of 138 samples from 85 kidney transplant patients with acute or chronic infections were simultaneously analyzed using mNGS and CT from July 2021 to August 2023.
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Assessment of community-acquired urinary tract infections treatment in the emergency department: a retrospective study.
Front Cell Infect Microbiol
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Infectious Diseases Department, Hôtel Dieu de France Hospital, Beirut, Lebanon.
Article Synopsis
- Urinary tract infections (UTIs) are common in emergency departments, and this study evaluated the necessity of broad-spectrum treatment for hospitalized patients with community-acquired UTIs (CAUTIs).
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Undetectable pre-radical cystectomy circulating tumour DNA status predicts improved oncological outcomes.
BJU Int
October 2024
Department of Urology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Objective: To assess recurrence-free survival (RFS) in patients with undetectable tumour-informed circulating tumour DNA (ctDNA) before radical cystectomy (RC) and evaluate if those who converted from detectable to undetectable ctDNA status after RC have similar RFS outcomes as those with persistently undetectable ctDNA status.
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The prognostic significance of circulating tumor DNA in patients with positive lymph node disease after robotic-assisted radical cystectomy: A contemporary analysis.
Urol Oncol
January 2025
Department of Urology, Icahn School of Medicine at Mount Sinai Hospital, New York, NY.
Background And Objective: Neoadjuvant therapy followed by radical cystectomy with lymphadenectomy remains the gold standard of treatment in patients with muscle-invasive bladder cancer. Pathologically positive lymph node (pN+) disease is known to convey a poor prognosis. Tumor-informed circulating tumor DNA (ctDNA) has emerged as a possible novel prognostic biomarker in the field.
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