Vibration-controlled transient elastography-based FibroScan (Echosens, Paris, France) is today considered the reference device for non-invasive assessment of liver stiffness, and has been found to be a good surrogate marker of liver fibrosis. One major issue when using VCTE™ is the necessity to find an optimal measurement window before triggering measurements. In this article, a new method called vibration-guided transient elastography (VGTE) facilitating the localization of an optimal measurement window is proposed. VGTE relies on a combination of continuous and transient vibrations used to locate the liver and to measure liver stiffness, respectively. Two studies conducted on customized phantoms and on 31 volunteers compared VGTE with standard ultrasound-based tools. VGTE performed significantly better than standard ultrasound-based tools in detection of an optimal measurement window. The operator never failed to find a valid measurement window using VGTE. VGTE can also detect artifacts such as lungs, ribs and blood vessels.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ultrasmedbio.2020.04.010DOI Listing

Publication Analysis

Top Keywords

measurement window
16
liver stiffness
12
optimal measurement
12
vibration-guided transient
8
transient elastography
8
standard ultrasound-based
8
ultrasound-based tools
8
vgte
6
liver
5
measurement
5

Similar Publications

RNA Translocation through Protein Nanopores: Interlude of the Molten RNA Globule.

J Am Chem Soc

January 2025

Department of Polymer Science and Engineering, University of Massachusetts, Amherst, Massachusetts 01003, United States.

Direct translocation of RNA with secondary structures using single-molecule electrophoresis through protein nanopores shows significant fluctuations in the measured ionic current, in contrast to unstructured single-stranded RNA or DNA. We developed a multiscale model combining the oxRNA model for RNA with the 3-dimensional Poisson-Nernst-Planck formalism for electric fields within protein pores, aiming to map RNA conformations to ionic currents as RNA translocates through three protein nanopores: α-hemolysin, CsgG, and MspA. Our findings reveal three distinct stages of translocation (pseudoknot, melting, and molten globule) based on contact maps and current values.

View Article and Find Full Text PDF

Background Multiple studies have shown that symptoms of knee osteoarthritis (OA) weakly correlate with the radiographic severity of the disease. Our objective was to determine possible correlations between the radiographic severity of knee OA and clinical manifestations such as disability, pain scores, and emotional health. Methods A retrospective review of registry data of 305 patients with knee OA was collected.

View Article and Find Full Text PDF

Impact of air pollution on the progress-free survival of non-small cell lung cancer patients with anti-PD-1/PD-L1 immunotherapy: a cohort study.

Environ Pollut

January 2025

Cancer Research Center, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing, China; Department of Medical Oncology, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing, China. Electronic address:

Air pollution is a well-established risk factor for lung cancer, but limited evidence exists on its impact on the treatment of lung cancer. The objective of this study was to investigate the impact of key pollutants on the efficacy of PD-1/PD-L1 inhibitor immunotherapy in non-small cell lung cancer (NSCLC) patients, thereby providing clinicians with evidence to potentially enhance the efficacy of PD-1 therapy and inform policy decisions for cancer care. To this end, we conducted a study involving 361 NSCLC patients who received PD-1/PD-L1 inhibitor immunotherapy, examining the correlation between air pollution exposure and progression-free survival (PFS) following immunotherapy treatment.

View Article and Find Full Text PDF

RADON in a high karst area of Montenegro - A case study.

Appl Radiat Isot

January 2025

School of Applied Mathematics and Informatics, University of Osijek, Trg Ljudevita Gaja 6, Osijek, Croatia.

The national radon surveys in Montenegro revealed that the highest annual average radon concentrations (C) in ground floors of dwellings and schools were found in a rural region characterized as a typical high-karst area. In this region, spanning approximately 800 km, C values in 9 houses and 16 schools ranged from 219 to 2494 Bq/m, with AM = 977 Bq/m. To investigate the causes of these elevated indoor radon concentrations, the following parameters were measured near the 25 surveyed buildings: soil humidity, electrical conductivity, pH, activity concentrations of Ra, U, U, Th and K, radon concentration in soil gas (c), soil permeability for radon gas (k), and gamma dose rate in the air.

View Article and Find Full Text PDF

Background: The ovarian cancer (OC) preclinical detectable phase (PCDP), defined as the interval during which cancer is detectable prior to clinical diagnosis, remains poorly characterised. We report exploratory analyses from the United Kingdom Collaborative Trial of Ovarian Cancer Screening (UKCTOCS).

Methods: In UKCTOCS between Apr-2001 and Sep-2005, 101,314 postmenopausal women were randomised to no screening (NS) and 50,625 to annual multimodal screening (MMS) (until Dec-2011) using serum CA-125 interpreted by the Risk of Ovarian Cancer Algorithm (ROCA).

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!