IMPDH-Based Cytoophidium Structures as Potential Theranostics in Cancer.

Mol Ther

Department of Pathology, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil.

Published: July 2020

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335744PMC
http://dx.doi.org/10.1016/j.ymthe.2020.06.006DOI Listing

Publication Analysis

Top Keywords

impdh-based cytoophidium
4
cytoophidium structures
4
structures potential
4
potential theranostics
4
theranostics cancer
4
impdh-based
1
structures
1
potential
1
theranostics
1
cancer
1

Similar Publications

IMP dehydrogenase rod/ring structures in acral melanomas.

Pigment Cell Melanoma Res

May 2020

Department of Pathology, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil.

Acral lentiginous melanoma (ALM) is a rare subtype of melanoma with aggressive behavior. IMPDH enzyme, involved in de novo GTP biosynthesis, has been reported to assemble into large filamentary structures called rods/rings (RR) or cytoophidium (cellular snakes). RR assembly induces a hyperactive state in IMPDH, usually to supply a high demand for GTP nucleotides, such as in highly proliferative cells.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!