AI Article Synopsis
- HER2-positive breast cancer was identified in the 1980s and is known for its aggressive nature, but targeted therapies have significantly improved patient outcomes.
- Current treatment guidelines established in 2012 recommend a dual blockade of trastuzumab and pertuzumab as first-line therapy, with TDM-1 for second-line treatment, but options become limited in later lines.
- Recent trials have introduced new drugs like tucatinib, neratinib, and trastuzumab-deruxtecan, prompting reevaluation of treatment sequencing, particularly in patients who have already received TDM-1, while emerging biomarkers could further influence treatment choices and effectiveness in the future.
Article Abstract
HER2-positive breast cancer is an aggressive subtype identified in the 1980s. The development of therapies targeting the HER2 has improved outcomes. The current standard of care, established in 2012 is dual blockade with trastuzumab + pertuzumab as first-line followed by TDM-1 as second-line. Several suboptimal choices are available in third-line or more. In 2019 the presentation of several trials evaluating new drugs and regimens in third-line has re-opened questions about sequencing, treatment of triple positive disease and treatment choice after exposure to TDM-1. These include tucatinib, neratinib and trastuzumab-deruxtecan. Other agents - including other antibody drug conjugates and bispecific antibodies as well as combinations - will lead to further changes in coming years. Additionally, should the numerous putative biomarkers thus identified ever come into use at the clinic, choice of treatment and response evaluation may be substantially changed.
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| http://dx.doi.org/10.1016/j.ctrv.2020.102033 | DOI Listing |
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