We present an 11-year-old girl who developed neutropenic fever and papulonodular lesions over her limbs and back following chemotherapy for relapsed acute myeloid leukemia. She was found to have cutaneous Trichosporon asahii infection, with no evidence of systemic infection, and responded to treatment with voriconazole. T. asahii infection is rare but often fatal and usually causes disseminated infections in immunocompromised patients. Cutaneous infection is relatively uncommon and rarely occurs in the pediatric population.
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Article Synopsis
- Trichosporon asahii is a harmful fungus that primarily affects people with weakened immune systems, leading to severe infections.
- Researchers faced challenges in studying its virulence due to the absence of effective animal models and genetic tools specific to this fungus.
- The study introduces a new method using silkworms for infection testing and a genetic technique to create mutants, aiding in the discovery of virulence factors associated with T. asahii.
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