Periodontal disease (PD) is common and increases cardiovascular diseases. However, it is unclear whether PD is associated with increased risk of dementia. We carried out a systematic review and meta-analysis to investigate the influence of PD on dementia. We projected the number of dementia cases to be saved by reducing PD prevalence in the world. We searched cohort and case-control studies reporting the association of PD with all dementia (or any specific type of dementia) through PubMed, MEDLINE, PsycINFO, SocINDEX, CINHAL, and CNKI until 7th November 2018. Five cohorts and seven case-control studies were identified for review. We pooled eligible data to calculate relative risk (RR) of dementia in relation to PD and computed the number of dementia cases saved through reducing PD prevalence. Of 12 studies, six were undertaken in Asia, four in Europe and two in America. Eleven studies showed a positive association between PD and the risk of dementia, of which 10 were significant, and one reported a non-significant inverse association. Overall their quality was good. Pooled RR of dementia in relation to PD from all high quality studies was 1.38 (95%CI 1.01-1.90); in the five cohorts was 1.18 (1.06-1.31) and in the two case-control studies 2.25 (1.48-3.42). A 50% reduction in the current prevalence of 20% of PD in the population could save 850,000 (630,000-1,420,000) patients with dementia in the world. PD could increase the risk of incident dementia. Preventing and treating PD could contribute to controlling the global epidemic of dementia.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s10654-020-00648-x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Daily activities and suspected dementia among community-dwelling older adults: a cross-sectional study.
BMC Geriatr
December 2024
School of Nursing and Rehabilitation, Nantong University, No.19 Qixiu Road, Nantong City, Jiangsu Province, China.
Background: Dementia is undiagnosed among many older adults, and more than half the people in local communities live with symptoms of dementia are not properly treated.
Objective: The study aims to explore the relationship between decline of daily activities and the incidence of suspected dementia.
Methods: A two-stage sampling method was used to conduct a multicenter cross-sectional survey.
Brain phosphoproteomic analysis identifies diabetes-related substrates in Alzheimer's disease pathology in older adults.
Alzheimers Dement
December 2024
Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.
Introduction: Type 2 diabetes increases the risk of Alzheimer's disease (AD) dementia. Insulin signaling dysfunction exacerbates tau protein phosphorylation, a hallmark of AD pathology. However, the comprehensive impact of diabetes on patterns of AD-related phosphoprotein in the human brain remains underexplored.
View Article and Find Full Text PDFPlasma phosphorylated tau and neuropsychiatric symptoms in dementia with Lewy bodies.
Alzheimers Dement
December 2024
Centre for Healthy Brain Ageing, Department of Psychological Medicine, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.
Introduction: Neuropsychiatric symptoms (NPSs) are common in dementia with Lewy bodies (DLB) but their neurobiological mechanisms are poorly understood.
Methods: NPSs and cognition were assessed annually in participants (DLB n = 222; Alzheimer's disease [AD] n = 125) from the European DLB (E-DLB) Consortium, and plasma phosphorylated tau-181 (p-tau181) and p-tau231 concentrations were measured at baseline.
Results: Hallucinations, delusions, and depression were more common in DLB than in AD and, in a subgroup with longitudinal follow-up, persistent hallucinations and NPSs were associated with lower p-tau181 and p-tau231 in DLB.
Early midlife ovarian removal is associated with lower posterior hippocampal function.
Alzheimers Dement
December 2024
Department of Psychology, University of Toronto, Toronto, Ontario, Canada.
Introduction: Women with early bilateral salpingo-oophorectomy (BSO) have greater Alzheimer's disease (AD) risk than women with spontaneous menopause (SM), but the pathway toward this risk is understudied. Considering associative memory deficits may reflect early signs of AD, we studied how BSO affected brain activity underlying associative memory.
Methods: Early midlife women with BSO (with and without 17β-estradiol therapy [ET]) and age-matched controls (AMCs) with intact ovaries completed a face-name associative memory task during functional magnetic resonance imaging.
Falls prevention in an older adult mental health ward through a quality improvement initiative.
BMJ Open Qual
December 2024
DIALOG Programme, Surrey and Borders Partnership NHS Foundation Trust, Leatherhead, UK.
Falls in the inpatient units are the most frequently reported patient safety incidents and their consequences can be devastating. Risk factors for falls are broadly categorised into two factors-'extrinsic and intrinsic' and while the effect of functional mental health conditions on falls has not been extensively studied, older adults with dementia are at a higher risk of falling. Their impact could lead to delayed functional recovery, distress, increased length of hospital stays and an increased fear of falling.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!