J Anat
Department of Anatomy, School of Medicine, University of Córdoba, Spain.
Published: October 1988
The morphology of the cartilage-marrow interface in chick embryo tibiae has been studied from Day 11 to Day 14. The cartilage-marrow interface did not present a uniform aspect and three different areas could be defined. Most of the interface was lined by fibroblast-like cells, macrophage-like cells and multinucleate giant cells. Other areas were characterised by a paucity of cells and by the presence of much cell debris. In focal areas the cartilage surface was excavated and covered by several layers of closely packed cells. These cells presented longitudinal axes perpendicular to the cartilage surface and were characterised ultrastructurally by the presence of large amounts of rough endoplasmic reticulum and large cytoplasmic processes extending into the matrix. The presence of different cell associations along the cartilage-marrow interface seems to suggest that uncalcified cartilage resorption follows a phasic pattern.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1262046 | PMC |
J Orthop Res
September 2004
Department of Orthopaedic Surgery, Yamagata University School of Medicine, Iida-Nishi 2-2-2, Yamagata 990-9585, Japan.
Vascular and cellular invasion into cartilage are essential for endochondral ossification. Recently it has been shown that matrix metalloproteinase-9 (MMP-9)/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes. To study vascular and cellular invasion into cartilage preceding primary endochondral ossification in long bones, precursor femurs from 13- to 16-day-old murine embryos were sectioned.
View Article and Find Full Text PDFJ Bone Miner Res
May 1997
Academic Orthopaedic Unit, University of Southampton, General Hospital, United Kingdom.
A detailed histological study of the growth plates from 9- to 20-day-old embryonic chick long bones was carried out with the aim of clarifying the long-debated question of the fate of the hypertrophic chondrocytes. Since resorption in chick bones does not occur synchronously across the plate as it does in mammals, specialized regions develop and the fate of the chondrocyte depends on its location within the growth plate. Where resorption took place, as at the sites of primary vascular invasion or at the main cartilage/marrow interface, chondrocytes underwent apoptosis before the lacunae were opened.
View Article and Find Full Text PDFConnect Tissue Res
May 1997
Academic Orthopaedic Unit, CF 86, General Hospital, Southampton, UK.
We have investigated the early cellular events that take place during the phenotypic switch from hypertrophic chondrocytes to bone-forming cells in a) chondrocytes located inside intact lacunae after embryonic chick femurs had been cut through the hypertrophic cartilage and cultured for 1-15 days; and b) at the cartilage/marrow interface of femurs after short-term culture. Ultrastructural studies were combined with in situ methods localizing proliferating and apoptotic cells, and 3D-reconstructions of confocal images of the cartilage/marrow edge. The crucial event in the phenotypic switch was an asymmetric cell division which resulted in one daughter cell which underwent apoptosis and another viable daughter cell which subsequently differentiated to an osteogenic cell, i.
View Article and Find Full Text PDFJ Anat
October 1988
Department of Anatomy, School of Medicine, University of Córdoba, Spain.
The morphology of the cartilage-marrow interface in chick embryo tibiae has been studied from Day 11 to Day 14. The cartilage-marrow interface did not present a uniform aspect and three different areas could be defined. Most of the interface was lined by fibroblast-like cells, macrophage-like cells and multinucleate giant cells.
View Article and Find Full Text PDFJ Anat
October 1987
Department of Anatomy, School of Medicine, University of Córdoba, Spain.
The cartilage dynamics in the tibia of dexamethasone-treated chick embryos has been studied by means of morphometric methods. Treated embryos showed a delay in the longitudinal growth of the tibia, as well as in the growth of all structures enclosed by the perichondrium-periosteum. The cartilage formation rate remained nearly unchanged (above 1 mm3/day) from Day 12 to Day 14, whereas the cartilage resorption rate was zero up to Day 13, and showed a non-significant increase from Day 13 onwards.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!
© LitMetric 2025. All rights reserved.