Discussion on targeting LXR and PPAR agonists as therapeutic alternatives to ustekinumab therapy in LAD-1.
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http://dx.doi.org/10.1002/JLB.5CE0520-122R | DOI Listing |
bioRxiv
November 2024
Computational Biology Branch, Division of Intramural Research, National Library of Medicine, National Institutes of Health, Bethesda, MD.
Prokaryote evolution is driven in large part by the incessant arms race with viruses. Genomic investments in antivirus defense can be coarsely classified into two categories, immune systems that abrogate virus reproduction resulting in clearance, and altruistic programmed cell death (PCD) systems. Prokaryotic defense systems are enormously diverse, as revealed by an avalanche of recent discoveries, but the basic ecological determinants of defense strategy remain poorly understood.
View Article and Find Full Text PDFTheor Popul Biol
February 2025
Fakultät für Biologie, Division of Evolutionary Biology, Ludwig-Maximilians-Universität München, Großhaderner Str. 2, 82152 Martinsried, Germany. Electronic address:
We model natural selection for or against an anti-parasite (or anti-predator) defense allele in a host (or prey) population that is structured into many demes. The defense behavior has a fitness cost for the actor compared to non defenders ("cheaters") in the same deme and locally reduces parasite growth rates. Hutzenthaler et al.
View Article and Find Full Text PDFDeath Stud
November 2024
The Culturally-Sensitive Clinical Psychology Program, Achva Academic College, Shikmim, Israel.
The aim of this study was to examine the case of altruistic kidney donation (AKD) following loss, in light of PTG theory. Loss may facilitate trauma alongside post-traumatic growth (PTG). Although much is known about the motivation for AKD in general, less is known about the motives of bereaved individuals who chose to altruistically donate their kidney post-loss.
View Article and Find Full Text PDFNeurooncol Pract
December 2024
Mark Hughes Foundation Centre for Brain Cancer Research, University of Newcastle, Newcastle, New South Wales, Australia.
Background: Brain cancer is a devastating and incurable disease that places a high burden of care on next of kin (NOK). NOK can play a core role in supporting end-of-life planning, including the decision to donate one's brain after death. Postmortem brain donation is crucial to research.
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