Synthesis and Pesticidal Activities of New Quinoxalines.

Natural products are a source of many novel compounds with biological activity for the discovery of new pesticides and pharmaceuticals. Quinoxaline is a fused -heterocycle in many natural products and synthetic compounds, and seven novel quinoxaline derivatives were designed and synthesized three steps. Pesticidal activities of title quinoxaline derivatives were bioassayed. Most of these compounds had herbicidal, fungicidal, and insecticidal activities. The compounds 2-(6-methoxy-2-oxo-3-phenylquinoxalin-1(2)-yl)acetonitrile () and 1-allyl-6-methoxy-3-phenylquinoxalin-2(1)-one () were the most active herbicides and fungicides. Mode-of-action studies indicated that is a protoprophyrinogen oxidase-inhibiting herbicide. Compound also possessed broad-spectrum fungicidal activity against the plant pathogen species. Some of these compounds also had insecticidal activity. Molecular docking and DFT analysis can potentially be used to design more active compounds.