Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304421PMC
http://dx.doi.org/10.1056/NEJMc2019373DOI Listing

Publication Analysis

Top Keywords

neuropathological features
4
features covid-19
4
neuropathological
1
covid-19
1

Similar Publications

Biopsy location and tumor-associated macrophages in predicting malignant glioma recurrence using an in-silico model.

NPJ Syst Biol Appl

January 2025

Center for Interdisciplinary Digital Sciences (CIDS), Department Information Services and High-Performance Computing (ZIH), Dresden University of Technology, 01062, Dresden, Germany.

Predicting the biological behavior and time to recurrence (TTR) of high-grade diffuse gliomas (HGG) after maximum safe neurosurgical resection and combined radiation and chemotherapy plays a pivotal role in planning clinical follow-up, selecting potentially necessary second-line treatment and improving the quality of life for patients diagnosed with a malignant brain tumor. The current standard-of-care (SoC) for HGG includes follow-up neuroradiological imaging to detect recurrence as early as possible and relies on several clinical, neuropathological, and radiological prognostic factors, which have limited accuracy in predicting TTR. In this study, using an in-silico analysis, we aim to improve predictive power for TTR by considering the role of (i) prognostically relevant information available through diagnostics used in the current SoC, (ii) advanced image-based information not currently part of the standard diagnostic workup, such as tumor-normal tissue interface (edge) features and quantitative data specific to biopsy positions within the tumor, and (iii) information on tumor-associated macrophages.

View Article and Find Full Text PDF

A multifaceted and widely prevalent neurodegenerative disease, Parkinson's disease (PD) is typified by the loss of dopaminergic neurons in the midbrain. The discovery of novel treatment(s) that can reverse or halt the course of the disease progression along with identifying the most reliable biomarker(s) in PD remains the crucial concern. RhoA in its active state has been demonstrated to interact with three distinct domains located in the central coiled-coil region of ROCK.

View Article and Find Full Text PDF

Neurodegenerative tauopathies are characterized by the deposition of distinct fibrillar tau assemblies, whose rigid core structures correlate with defined neuropathological phenotypes. Essential tremor (ET) is a progressive neurological disorder that, in some cases, is associated with cognitive impairment and tau accumulation. In this study, we explored tau assembly conformation in ET patients with tau pathology using cytometry-based tau biosensor assays.

View Article and Find Full Text PDF

Cognitive impairment is a core feature of neurodevelopmental (schizophrenia) and aging-associated (mild cognitive impairment and Alzheimer's dementia) neurodegenerative diseases. Limited efficacy of current pharmacological treatments warrants further search for new targets for nootropic interventions. The breakdown of myelin, a phospholipids axonal sheath that protects the conduction of nerve impulse between neurons, was proposed as a neuropathological abnormality that precedes and promotes the deposition of amyloid-β in neuritic plaques.

View Article and Find Full Text PDF
Article Synopsis
  • Alzheimer's disease (AD) is characterized by cognitive decline and specific brain changes, necessitating the development of effective animal models to study it.
  • Current transgenic mouse models have limitations in capturing the full complexity of human AD pathology and their interactions.
  • The novel APP/PS1-TauP301L-Adeno mouse model enhances understanding of AD mechanisms by inducing significant pathological symptoms, revealing the exacerbating effect of severe reactive astrogliosis on amyloid-β plaques and neurofibrillary tangles.
View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!