AI Article Synopsis
- - Statins have been found beneficial in preventing cardiovascular events, especially in older adults, but their effectiveness in this age group is still debated.
- - A review of 17 trials showed that statins significantly reduced the risk of serious health issues like all-cause mortality and heart problems when used for secondary prevention, while having limited effects in primary prevention.
- - Among different statin medications, intensive atorvastatin showed the most significant benefits for secondary prevention in elderly patients, but overall differences between statins had minimal impact on therapy effectiveness.
Article Abstract
Objective: Statins have been shown to be beneficial for the prevention of cardiovascular events. In elderly individuals, the efficacy of statins remains controversial and the comparative effect of statins has not been assessed.
Methods: MEDLINE, Embase, and the Cochrane Central database were searched for randomized controlled trials that assessed statins in older patients.
Results: Seventeen trials were analyzed. When used for secondary prevention, statins were associated with reduced risk of cardiovascular events, all-cause mortality, cardiovascular mortality, revascularization, and stroke. When used for primary prevention, statins reduced the risk of myocardial infarction and revascularization, but did not significantly affect other outcomes. A modest difference between pharmaceutical statin products was found, and high-quality evidence indicated that intensive atorvastatin had the greatest benefits for secondary prevention.
Conclusions: In secondary prevention, evidence strongly suggests that statins are associated with a reduction in the risk of all-cause mortality, cardiovascular events, cardiovascular mortality, and revascularization. However, differences in the effects of various statins do not appear to have significant effects on therapy in secondary prevention for the elderly.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294495 | PMC |
| http://dx.doi.org/10.1177/0300060520926349 | DOI Listing |
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