Segmentation and 3D reconstruction of the human atria is of crucial importance for precise diagnosis and treatment of atrial fibrillation, the most common cardiac arrhythmia. However, the current manual segmentation of the atria from medical images is a time-consuming, labor-intensive, and error-prone process. The recent emergence of artificial intelligence, particularly deep learning, provides an alternative solution to the traditional methods that fail to accurately segment atrial structures from clinical images. This has been illustrated during the recent 2018 Atrial Segmentation Challenge for which most of the challengers developed deep learning approaches for atrial segmentation, reaching high accuracy (>90% Dice score). However, as significant discrepancies exist between the approaches developed, many important questions remain unanswered, such as which deep learning architectures and methods to ensure reliability while achieving the best performance. In this paper, we conduct an in-depth review of the current state-of-the-art of deep learning approaches for atrial segmentation from late gadolinium-enhanced MRIs, and provide critical insights for overcoming the main hindrances faced in this task.
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http://dx.doi.org/10.3389/fcvm.2020.00086 | DOI Listing |
Int J Surg
January 2025
Department of Cardiovascular Surgery, Xijing Hospital, Xi'an, Shaanxi, China.
Background: The impact of aortic arch (AA) morphology on the management of the procedural details and the clinical outcomes of the transfemoral artery (TF)-transcatheter aortic valve replacement (TAVR) has not been evaluated. The goal of this study was to evaluate the AA morphology of patients who had TF-TAVR using an artificial intelligence algorithm and then to evaluate its predictive value for clinical outcomes.
Materials And Methods: A total of 1480 consecutive patients undergoing TF-TAVR using a new-generation transcatheter heart valve at 12 institutes were included in this retrospective study.
Int J Surg
January 2025
Department of Trauma and Emergency Surgery, Chang Gung Memorial Hospital, Linkou; Chang Gung University, Taoyuan, Taiwan.
Background: Detecting kidney trauma on CT scans can be challenging and is sometimes overlooked. While deep learning (DL) has shown promise in medical imaging, its application to kidney injuries remains underexplored. This study aims to develop and validate a DL algorithm for detecting kidney trauma, using institutional trauma data and the Radiological Society of North America (RSNA) dataset for external validation.
View Article and Find Full Text PDFJ Chem Inf Model
January 2025
Industrial and Molecular Pharmaceutics, Purdue University, West Lafayette, Indiana 47907, United States.
Drug-drug interaction can lead to diminished therapeutic effects or increased toxicity, posing significant risks, especially in polypharmacy, and cytochrome P450 plays an indispensable role in this interaction. Cytochrome P450, responsible for the metabolism and detoxification of most drugs, metabolizes about 90% of Food and Drug Administration-approved drugs, making early detection of potential drug-drug interactions. Over the years, in-silico modeling has become a valuable tool for predicting drug-drug interactions.
View Article and Find Full Text PDFJ Mater Chem B
January 2025
Biomaterials Drug Delivery and Nanotechnology Unit, Centre for Biomedical and Biomaterials Research (CBBR), University of Mauritius, Réduit, Mauritius.
Tissue regeneration after a wound occurs through three main overlapping and interrelated stages namely inflammatory, proliferative, and remodelling phases, respectively. The inflammatory phase is key for successful tissue reconstruction and triggers the proliferative phase. The macrophages in the non-healing wounds remain in the inflammatory loop, but their phenotypes can be changed interactions with nanofibre-based scaffolds mimicking the organisation of the native structural support of healthy tissues.
View Article and Find Full Text PDFAnal Chem
January 2025
State Key Laboratory of Cellular Stress Biology, Institute of Artificial Intelligence, School of Life Sciences, Faculty of Medicine and Life Sciences, National Institute for Data Science in Health and Medicine, XMU-HBN skin biomedical research center, Xiamen University, Xiamen, Fujian 361102, China.
In metabolomic analysis based on liquid chromatography coupled with mass spectrometry, detecting and quantifying intricate objects is a massive job. Current peak picking methods still cause high rates of incorrectly picked peaks to influence the reliability and reproducibility of results. To address these challenges, we developed QuanFormer, a deep learning method based on object detection designed to accurately quantify peak signals.
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