AI Article Synopsis
- This study investigates the relationship between GLP-1 receptor gene variations (SNPs) and bone mineral density (BMD) in postmenopausal women in Shanghai.
- Out of eight SNPs analyzed, the A/A genotype of rs2295006 showed a negative correlation with BMD in the lumbar spine and the A allele was linked to lower hip BMD.
- The findings suggest that the rs2295006 SNP may influence bone health in postmenopausal women, while other SNPs studied did not show a significant effect on BMD.
Article Abstract
Background: Glucagon-like peptide-1 receptor (GLP-1R) agonists are able to inhibit bone resorption to a certain extent and improve bone formation. GLP-1R single nucleotide polymorphism (SNP) is related to its activity, but the relationship between GLP-1R SNP and osteoporosis in postmenopausal women was still unclear. This study was to investigate the association between GLP-1R SNP and bone mineral density (BMD) in postmenopausal women in Shanghai.
Methods: Eight SNPs of GLP-1R were detected (rs3765467, rs1042044, rs2268657, rs6923761, rs2268641, rs2295006, rs4714210 and rs10305420) in 884 postmenopausal women in Shanghai. The correlation between GLP-1R SNP and BMD was further assessed.
Results: The A/A genotype of rs2295006 was negatively related to lumbar vertebrae 1-4 BMD (P<0.05). Allele A was negatively related to hip BMD (P<0.05). There was a negative correlation between haplotype CGAGCCA and lumbar BMD, and a positive correlation between haplotype CGGGCTA and lumbar BMD. The remaining seven GLP-1R SNPs had no relationship with BMD.
Conclusions: The rs2295006 of GLP-1R is related to the BMD of postmenopausal women in Shanghai, China.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.21037/apm-19-396 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Enhancing detection of previously missed non-palpable breast carcinomas through artificial intelligence.
Eur J Radiol Open
June 2025
Radiology Department, National Cancer Institute, Cairo University, Egypt.
Purpose: To investigate the impact of artificial intelligence (AI) reading digital mammograms in increasing the chance of detecting missed breast cancer, by studying the AI- flagged early morphology indictors, overlooked by the radiologist, and correlating them with the missed cancer pathology types.
Methods And Materials: Mammograms done in 2020-2023, presenting breast carcinomas (n = 1998), were analyzed in concordance with the prior one year's result (2019-2022) assumed negative or benign. Present mammograms reviewed for the descriptors: asymmetry, distortion, mass, and microcalcifications.
Müllerianosis of the urinary bladder in pre- and postmenopausal women: a literature review.
Prz Menopauzalny
December 2024
Department of Urology, University Hospital of Alexandroupolis, Democritus University of Thrace, Alexandroupolis, Greece.
Müllerianosis of the urinary bladder is a rare pathological condition involving ectopic Müllerian-derived tissues within the bladder. Despite its benign nature, due to its ability to mimic malignant conditions such as bladder carcinoma, diagnosis might be challenging. In this review, data from 36 cases across 32 studies were analyzed, focusing on patient demographics, symptomatology, diagnostic imaging, and histopathological features.
View Article and Find Full Text PDFAssociation of age at menopause with type 2 diabetes mellitus in postmenopausal women: a systematic review and meta-analysis.
Prz Menopauzalny
December 2024
Department of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
The onset of menopause usually occurs between the ages of 48 and 52, leading to diverse symptoms in various body systems due to a decrease in estrogen level. Visceral obesity and diminished estrogen level during the menopausal phase are associated with unfavorable metabolic changes, resulting in insulin resistance and increased risk of type 2 diabetes mellitus (T2DM). Owing to the increase in the incidence and prevalence of T2DM in recent decades, it is important to identify predisposing factor such as menopausal age to improve T2DM prevention and management.
View Article and Find Full Text PDFDiagnostic value and fracture healing-preventing effect of upregulated microRNA-4534 in patients with osteoporotic fractures.
J Formos Med Assoc
January 2025
Department of Rehabilitation Medicine, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, 533000, China. Electronic address:
Background: Osteoporosis fracture is a common and most serious complication of osteoporosis.
Hypothesis: This study sought to assess the level, the diagnostic potential, and the effect of circulating miR-4534 in osteoporotic fractures.
Methods: GSE74209 and GSE93883 were analyzed using GEO2R online tool for differentially expressed microRNAs in osteoporotic fractures.
Gut microbiota and short-chain fatty acids signatures in postmenopausal osteoporosis patients: A retrospective study.
Medicine (Baltimore)
November 2024
Department of Endocrinology, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, P. R. China.
Studies have shown that gut microbiota (GM) and its metabolites, short-chain fatty acids (SCFAs), are associated with the development of postmenopausal osteoporosis (PMO). This study explored the clinical and laboratory evidence of the relationship of GM and SCFAs to PMO and attempted to determine the potential mechanism of action. 18 patients (Collected from the First Affiliated Hospital of Guangdong Pharmaceutical University between January 2021 and August 2021) were included in this retrospective study, including 10 PMO women and 8 healthy young women as the healthy control (HC) group from Guangzhou, China.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!