Intensive longitudinal designs (e.g., experience sampling methods, daily diary studies, or ambulatory assessments) continue to gain importance in psychological aging research. Empirical research using these designs has greatly facilitated our understanding of short-term within-person processes and has started to approach the question how these processes shape long-term development across the life span. The aim of this viewpoint article is to point out four key issues in intensive longitudinal designs that in our opinion require more attention than they are currently given: (a) improvement in measurement reliability, (b) the necessity to investigate inter-individual differences in short-term dynamics, (c) considerations of the time scale across which dynamic effects unfold, and (d) targeting causality by incorporating experimental methods in intensive longitudinal designs. We illustrate these four key issues by referring to a prominent example of within-person dynamics in prior empirical research: the within-person coupling of stressor occurrence and well-being (stress reactivity).
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http://dx.doi.org/10.1159/000507993 | DOI Listing |
Background: The development and approval of novel drugs are typically time-intensive and expensive. Leveraging a computational drug repurposing framework that integrates disease-relevant genetically regulated gene expression (GReX) and large longitudinal electronic medical record (EMR) databases can expedite the repositioning of existing medications. However, validating computational predictions of the drug repurposing framework remains a challenge.
View Article and Find Full Text PDFOphthalmol Sci
November 2024
Casey Eye Institute, Oregon Health and Science University, Portland, Oregon.
Purpose: Retinopathy of prematurity (ROP) stage is defined by the visual appearance of the vascular-avascular border, which reflects a spectrum of pathologic neurovascular tissue (NVT). Previous work demonstrated that the thickness of the ridge lesion, measured using OCT, corresponds to higher clinical diagnosis of stage. This study evaluates whether the volume of anomalous NVT (ANVTV), defined as abnormal tissue protruding from the regular contour of the retina, can be measured automatically using deep learning to develop quantitative OCT-based biomarkers in ROP.
View Article and Find Full Text PDFNutrients
January 2025
Clinical Nutrition Unit, ASL Città di Torino, 10128 Turin, Italy.
The impact of home parenteral nutrition (HPN) on the quality of life (QoL) of cancer patients has been previously investigated. However, scarce data are available regarding near-death QoL in patients with cancer receiving HPN. This study aims to investigate the changes of QoL in these patients in the last two months before death.
View Article and Find Full Text PDFJ Clin Med
January 2025
Clinical Pharmacology and Pharmacotherapy, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, 3000 Leuven, Belgium.
Substance use during pregnancy is associated with adverse outcomes for both mother and child. This study aimed to determine the prevalence and determinants of alcohol, tobacco and illicit drug use before and during pregnancy in Belgium. An observational study was conducted using data from the longitudinal BELpREG registry.
View Article and Find Full Text PDFJ Clin Med
January 2025
Department of Nephrology and Medical Intensive Care, Charité-Universitätsmedizin Berlin, 22083 Berlin, Germany.
Predictive machine learning models have made use of a variety of scoring systems to identify clinical deterioration in ICU patients. However, most of these scores include variables that are dependent on medical staff examining the patient. We present the development of a real-time prediction model using clinical variables that are digital and automatically generated for the early detection of patients at risk of deterioration.
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