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| http://dx.doi.org/10.1159/000509002 | DOI Listing |
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Diagnostic Models for Differentiating COVID-19-Related Acute Ischemic Stroke Using Machine Learning Methods.
Diagnostics (Basel)
December 2024
Department of Biostatistics, Hacettepe University, 06230 Ankara, Türkiye.
Although COVID-19 is primarily known as a respiratory disease, there is growing evidence of neurological complications, such as ischemic stroke, in infected individuals. This study aims to evaluate the impact of COVID-19 on acute ischemic stroke (AIS) using radiomic features extracted from brain MR images and machine learning methods. This retrospective study included MRI data from 57 patients diagnosed with AIS who presented to the Department of Radiology at Hacettepe University Hospital between March 2020 and September 2021.
View Article and Find Full Text PDFExtensive Left Ventricular Thrombosis after Recovery from COVID-19: A Case Report.
Tanaffos
January 2024
Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Coagulation disorder is common among COVID-19 patients, particularly those afflicted with the severe form of the disease. Manifestations of thrombotic complications such as pulmonary embolism, deep vein thrombosis (DVT), ischemic stroke, cardiac infarction and arterial embolism is high in COVID-19 patients which have been assessed in various studies (5).It seems that COVID-19-related coagulopathy is a combination of low-grade DIC and pulmonary thrombotic microangiopathy which can have a significant effect on organ dysfunction in patients with severe COVID-19 (6).
View Article and Find Full Text PDFEvaluating diclofenac's risks in COVID-19: strategies for mitigating adverse outcomes.
Inflammopharmacology
November 2024
School of Pharmacy, International Medical University, Kuala Lumpur, Malaysia.
The use of nonsteroidal anti-inflammatory drugs (NSAIDs), particularly diclofenac, during the COVID-19 pandemic has raised concerns due to its potential to worsen disease progression. This commentary evaluates key risks associated with diclofenac and highlights the critical role of pharmacists in mitigating adverse outcomes through careful medication management and patient education. Diclofenac poses unique risks due to its ability to generate reactive oxygen species (ROS), leading to oxidative stress and mitochondrial dysfunction.
View Article and Find Full Text PDFThe relationship between COVID-19 and ischemic stroke (IS) has attracted significant attention, yet the precise mechanism at the gene level remains unclear. This study aims to reveal potential biomarkers and drugs for COVID-19-related IS through bioinformatics methods. We collected two gene expression profiling datasets, GSE16561 and GSE213313, and selected GSE179879 and GSE196822 as validation sets for analysis.
View Article and Find Full Text PDFTreatment of cerebral venous thrombosis: a review.
Curr Med Res Opin
December 2024
The Aga Khan University, Neurology, Department of Medicine, Aga Khan University, Karachi, Pakistan.
Article Synopsis
- Cerebral venous thrombosis (CVT) is a rare type of stroke that may be linked to COVID-19 infection and vaccinations, with the management evolving to include fibrinolysis and mechanical thrombectomy.
- A literature review highlighted that low-molecular-weight heparin (LMWH) and unfractionated heparin (UH) are the recommended first-line treatments for acute CVT, while warfarin can be used later for prevention, although DOACs show promise as alternatives.
- Treatment approaches for COVID-19 related CVT are similar to non-COVID-19 CVT, but vaccine-related CVT requires different strategies involving non-heparin anticoagulants and possibly immunotherapy or steroids, emphasizing the
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