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Medication use is associated with distinct microbial features in anxiety and depression.
Mol Psychiatry
January 2025
Department of Pediatrics, University of California San Diego, La Jolla, CA, USA.
This study investigated the relationship between gut microbiota and neuropsychiatric disorders (NPDs), specifically anxiety disorder (ANXD) and/or major depressive disorder (MDD), as defined by Diagnostic and Statistical Manual of Mental Disorders (DSM)-IV or V criteria. The study also examined the influence of medication use, particularly antidepressants and/or anxiolytics, classified through the Anatomical Therapeutic Chemical (ATC) Classification System, on the gut microbiota. Both 16S rRNA gene amplicon sequencing (16S) and shallow shotgun sequencing (WGS) were performed on DNA extracted from 666 fecal samples from the Tulsa-1000 and Neurocomputational Mechanisms of Affiliation and Personality Study Center for Biomedical Research Excellence (NeuroMAP CoBRE) cohorts.
View Article and Find Full Text PDFThe α-synuclein seed amplification assay: Interpreting a test of Parkinson's pathology.
Parkinsonism Relat Disord
December 2024
Department of Translational Neuroscience and the Muhammad Ali Parkinson Center, Barrow Neurological Institute, Phoenix, AZ, USA.
The α-synuclein seed amplification assay (αSyn-SAA) sensitively detects Lewy pathology, the amyloid state of α-synuclein, in the cerebrospinal fluid (CSF) of patients with Parkinson's disease (PD). The αSyn-SAA harnesses the physics of seeding, whereby a superconcentrated solution of recombinant α-synuclein lowers the thermodynamic threshold (nucleation barrier) for aggregated α-synuclein to act as a nucleation catalyst ("seed") to trigger the precipitation (nucleation) of monomeric α-synuclein into pathology. This laboratory setup increases the signal for identifying a catalyst if one is present in the tissue examined.
View Article and Find Full Text PDFRoom temperature synthesis of one-dimensional hierarchical hollow BiOBr with tunable photocatalysis reaction pathway for RhB under visible light.
Environ Res
January 2025
Jiangxi Province Key Laboratory of Surface Engineering,Jiangxi Science & Technology Normal University, Nanchang 330013, PR China; School of Materials and Energy, Jiangxi Science & Technology Normal University, Nanchang 330013, P. R. China. Electronic address:
One-dimensional (1D) hierarchical photocatalyst has the advantages of 1D materials and hierarchical materials, which is a kind of potential high performance photocatalytic materials. However, how to efficiently synthesize 1D hierarchical BiOBr is still a huge challenge. Herein, 1D rod-like BiO(OH)(NO)·3HO, the hydrolysis product of Bi(NO)·5HO, was acted as both the template and Bi source to synthesize 1D hierarchical hollow BiOBr (1DHHBr) through a facile solution stirring method at room temperature, using KBr as Br source.
View Article and Find Full Text PDFEfficacy and Safety of Shexiang Baoxin Pill (MUSKARDIA) in Patients with Stable Coronary Artery Disease Across Different Weight Subgroups.
J Ethnopharmacol
January 2025
Department of Cardiovascular Internal Medicine, Zhongshan Hospital, Fudan University, Shanghai 200000, China.
Ethnopharmacological Relevance: Shexiang Baoxin Pill (MUSKARDIA), a traditional Chinese patent medicine, plays a crucial role in both preventing and treating diverse cardiovascular diseases, including coronary heart disease, myocardial infarction (MI), and heart failure. Preclinical research has demonstrated that the cardioprotective effects of MUSKARDIA are achieved through multiple pathways, such as enhancing coronary artery dilation, fostering new blood vessel growth, reducing inflammation and oxidative stress, improving lipid metabolism, and protecting vascular endothelium.
Aim Of The Study: This subgroup analysis aimed to evaluate the efficacy and safety of Shexiang Baoxin Pill (MUSKARDIA) plus optimal medical therapy (OMT) across different weight categories in treating stable coronary artery disease (CAD).
Lead time trajectory of blood-based protein biomarkers for detection of pancreatic cancer based on repeat testing.
Cancer Lett
January 2025
Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA, 77030. Electronic address:
In the current study, we assessed whether repeated measurements of a panel of protein biomarkers with relevance to pancreatic ductal adenocarcinoma (PDAC) improves lead time performance for earlier detection over a single timepoint measurement. Specifically, CA125, CEA, LRG1, REG3A, THBS2, TIMP1, TNRFSF1A as well as CA19-9 were assayed in serially collected pre-diagnostic plasma from 242 PDAC cases and 242 age- and sex-matched non-case control participants in the PLCO cohort. We compared performance estimates of a parametric empirical Bayes (PEB) algorithm, which incorporates participant biomarker history, to that of a single-threshold (ST) method.
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