AI Article Synopsis
- The study examined the epididymal epithelium in adult castrated rhesus monkeys using a transmission electron microscope, noting structural changes in the epididymis after 90 days of castration.
- Key observations included reduced tubular diameter, decreased microvilli, diminished endoplasmic reticulum and Golgi complex, and accumulation of mitochondria and vacuoles, indicating impaired absorptive and secretory functions of the principal cells.
- After 30 days of androgen replacement therapy, structural features of the epithelium partially recovered to a near-normal state, suggesting the role of androgens in maintaining epididymal health.
Article Abstract
The epididymal epithelium from adult castrated and androgen supplemented, castrated rhesus monkeys was examined with transmission electron microscope. Ninety days after bilateral castration the tubular diameter of all the regions of the epididymis, viz. the initial segment, caput, corpus and cauda portions of epididymis was reduced and was accompanied by a drop in cell size. There was a marked decrease in the number and size of microvilli on the luminal surface. The invaginations of apical membrane into the cell cytoplasm became less prominent. There was a reduction in the amount of smooth and rough endoplasmic reticulum, and Golgi complex. Mitochondria accumulated in the apical cytoplasm. Several vacuoles often associated with lipofuscin pigment granules were common in the cytoplasm. These findings suggest a reduction in both the absorptive and secretory functions of the principal cells. Following androgen replacement therapy for 30 days in monkeys that were castrated 60 days earlier there was a recovery of structural features in the epithelium to near normal state.
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