The cell-mediated immunity was investigated by delayed hypersensitivity reactions on recall antigens (tetanus, diphtheria, streptococci, tuberkulin, candida, trichophyton, proteus/Multitest-Merieux) in 56 patients with atopic dermatitis (34 females, 22 males) under mountain-climatic therapy (Davos, 5118 ft). The testscore of 7.9 mm (females 8.2/males 7.5) was lowered in comparison to the normals within the literature (females 15.4/males 21.0). Anergy was found in 8.8% in females (normal 4%) and in 9.1% in males (0.4%). After treatment the score raised up to 9.9 mm (25.3%, p less than 0.005), more obvious in males (29.3%/9.7 mm) than in females (22.0%/10.0 mm). The mean number of positive skin-reactions raised from 2.0 to 2.6 (p less than 0.001). These data let assume an influence of mountain-climatic therapy on the cell-mediated immunity.
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