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Addressing Drug Shortages at Mediclinic Parkview Hospital: A Five-Year Study of Challenges, Impact, and Strategies.
Cureus
December 2024
Department of Pharmacy, Mediclinic Parkview Hospital, Mediclinic Middle East, Dubai, ARE.
Background Drug shortages have become a significant challenge globally, affecting healthcare delivery and patient outcomes. This study aimed to assess drug shortages' prevalence, causes, and impact at a tertiary care hospital in Dubai, the United Arab Emirates (UAE), providing actionable insights for future mitigation strategies. Methods A retrospective descriptive study was conducted at Mediclinic Parkview (MPAR) Hospital, part of Mediclinic Middle East (MCME), UAE.
View Article and Find Full Text PDFThe Role of Structural Flexibility in Hydrocarbon-Stapled Peptides Designed to Block Viral Infection via Human ACE2 Mimicry.
Pept Sci (Hoboken)
November 2024
Department of Pediatrics, Section of Hematology/Oncology, The University of Chicago, Chicago, Illinois 60637, United States of America.
The COVID-19 pandemic drove a uniquely fervent pursuit to explore the potential of peptide, antibody, protein, and small-molecule based antiviral agents against severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2). The interaction between the SARS-CoV2 spike protein with the angiotensin-converting enzyme 2 (ACE2) receptor that mediates viral cell entry was a particularly interesting target given its well described protein-protein interaction (PPI). This PPI is mediated by an α-helical portion of ACE2 binding to the receptor binding domain (RBD) of the spike protein and thought to be susceptible to blockade through molecular mimicry.
View Article and Find Full Text PDFDeep Drug-Target Binding Affinity Prediction Base on Multiple Feature Extraction and Fusion.
ACS Omega
January 2025
School of Computer Science and Technology, Zhejiang Sci-Tech University, Hangzhou 310018, China.
Accurate drug-target binding affinity (DTA) prediction is crucial in drug discovery. Recently, deep learning methods for DTA prediction have made significant progress. However, there are still two challenges: (1) recent models always ignore the correlations in drug and target data in the drug/target representation process and (2) the interaction learning of drug-target pairs always is by simple concatenation, which is insufficient to explore their fusion.
View Article and Find Full Text PDFExploring Breastfeeding Mothers' and Lactation Consultants' Experiences of Lactation Consultancy Throughout the Restrictions Put in Place Due to the COVID-19 Pandemic.
HRB Open Res
December 2024
Dublin City University, Dublin, Leinster, Ireland.
Background: Breastfeeding rates in Ireland are among the lowest in the world. Lactation consultancy provides mothers with support and information on how to cope with any challenges they encounter. There is emerging evidence that COVID-19 restrictions impacted access to and the quality of breastfeeding support.
View Article and Find Full Text PDFSARS-COV-2 re-infection and incidence of post-acute sequelae of COVID-19 (PASC) among essential workers in New York: a retrospective cohort study.
Lancet Reg Health Am
February 2025
World Trade Center Health Program, Renaissance School of Medicine, Stony Brook University, NY, USA.
Background: After surviving Coronavirus Disease 2019 (COVID-19), some people develop symptoms known as post-acute sequelae of COVID-19 (PASC). PASC is an emerging phenomenon yet to be fully understood, and identifying risk factors has been challenging. This study investigated the association between the number of COVID-19 episodes and the incidence of PASC among essential workers.
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