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Bioactive hydroxypropionylated glucose derivatives from . | LitMetric
Four previously undescribed hydroxypropionylated d-glucose derivatives, astrabhotins A-D (-), along with ten known compounds -d-glucose (), -d-glucose (), quebrachitol (), 3-hydroxypropionic acid (), oleic acid (), isoliquiritigenin (), liquiritigenin (), odoratin (), 7-hydroxysitosterol () and daucosterol (), were isolated from the roots of . Their structures were elucidated based on the analyses of extensive spectroscopic data and physicochemical properties. Astrabhotin A () reduced the writhing response remarkably with 52.5% inhibition by acetic acid induced writhing test. The analgesic effect of was stronger than the standard drug aspirin. In addition, compounds and showed significant antioxidant activities with IC values of 9.9 ± 0.2 and 7.9 ± 0.4 μg/mL, and exhibited weak or moderate cytotoxicity against HepG2 cells with IC values of 106.6 ± 2.7 and 42.0 ± 0.9 μg/mL, respectively.[Figure: see text].
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