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Metabolic Dysfunction-Associated Steatotic Liver Disease Is Accompanied by Increased Activities of Superoxide Dismutase, Catalase, and Carbonyl Reductase 1 and Levels of miR-200b-3p in Mouse Models.
Antioxidants (Basel)
November 2024
Department of Biochemical Sciences, Faculty of Pharmacy in Hradec Králové, Charles University, 50003 Hradec Králové, Czech Republic.
Metabolic dysfunction-associated steatotic liver disease (MASLD), one of the leading causes of chronic liver disorders, is characterized by hepatic lipid accumulation. MASLD causes alterations in the antioxidant defense system, lipid, and drug metabolism, resulting in impaired antioxidant status, hepatic metabolic processes, and clearance of therapeutic drugs, respectively. In the MASLD pathogenesis, dysregulated epigenetic mechanisms (e.
View Article and Find Full Text PDFImaging human coronary cholesterol/urate crystals with cross-polarized micro-optical coherence tomography.
Front Cardiovasc Med
October 2024
Wellman Center for Photomedicine, Harvard Medical School and Massachusetts General Hospital, Boston, MA, United States.
Introduction: Birefringent crystals such as monosodium-urate (MSU) and cholesterol crystals (CC) likely contribute to the progression of coronary artery disease (CAD) due to their potential to exacerbate inflammation through inflammatory cytokine activation. Here, we present cross-polarized micro-optical coherence tomography (CP-µOCT) for visualizing individual birefringent crystals in human coronary arteries.
Methods And Results: Human cadaver coronary arteries with a history of CAD with or without gout were dissected for CP-µOCT imaging.
Indolelactic acid as a potential metabolic biomarker for diagnosing gout.
Exp Ther Med
November 2024
Department of Rheumatology and Immunology, The Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing, Jiangsu 210029, P.R. China.
Article Synopsis
- Gout is a complex disease caused by the buildup of monosodium urate crystals in joints, and its causes are not fully understood, highlighting the need for new biomarkers for early detection and diagnosis.
- A study analyzed serum samples from 47 gout patients and 49 healthy individuals using advanced metabolomics techniques, identifying 186 metabolites that significantly differed between the two groups, with 156 upregulated and 30 downregulated in gout patients.
- Among the findings, indolelactic acid (ILA) emerged as a potential biomarker for gout, and the study suggested that pathways related to D-glutamine and D-glutamate metabolism may play crucial roles in the disease's development.
[ Capsule alleviates inflammation and uric acid and lipid metabolism imbalance in rats with gouty arthritis by inhibiting the PTEN/PI3K/AKT signaling pathway].
Nan Fang Yi Ke Da Xue Xue Bao
August 2024
Anhui University of Chinese Medicine, Hefei 230012, China.
Article Synopsis
- * Rats with GA showed significant foot swelling and inflammation, measured through various biological markers and tissue analysis, peaking at 48 hours post-treatment.
- * HQC and colchicine improved inflammation and regulated uric acid and lipid levels in the rats, likely by influencing the PTEN/PI3K/AKT signaling pathway.
Effect of monosodium glutamate supplementation in diet on fatty acid profiles, genes expression related to lipid metabolism and egg yolk cholesterol in late phase of production in laying hens.
J Anim Physiol Anim Nutr (Berl)
September 2024
Department of Animal Science, Sari Agricultural Sciences and Natural Resources University, Sari, Iran.
In an experiment with four treatments and five replicates, the effects of adding monosodium glutamate (MSG) to the diet in late phase of egg production was studied on performance, and lipid metabolism in laying hens. Dietary treatments included the control basal diet without MSG and the other treatments adding 0.4%, 0.
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