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Impact of psychotropic pro re nata prescription-monitoring programme on prescriptions for inpatients with psychiatric disorders: a retrospective observational study.
BMC Psychiatry
January 2025
Department of Psychiatry, Kitasato University, School of Medicine, 1-15-1 Kitasato, Minami-Ku, Sagamihara, Kanagawa, 252-0374, Japan.
Background: Pro re nata (PRN) medication is used "as needed" for symptoms such as agitation and insomnia, in addition to regular daily pharmacotherapy of mental disorders. However, there is no high-quality evidence on the effectiveness of psychotropic PRN medications and concerns have been raised about their potential to contribute to polypharmacy. This study introduced a psychotropic PRN prescription-monitoring programme for psychiatric inpatients with the aim of examining the change before and after the implementation of the programme.
View Article and Find Full Text PDFA reproducible representation of healthy tibiofemoral kinematics during stair descent using REFRAME - part I: REFRAME foundations and validation.
Sci Rep
January 2025
Research and Development, Aesculap AG, Tuttlingen, Germany.
In clinical movement biomechanics, kinematic measurements are collected to characterise the motion of articulating joints and investigate how different factors influence movement patterns. Representative time-series signals are calculated to encapsulate (complex and multidimensional) kinematic datasets succinctly. Exacerbated by numerous difficulties to consistently define joint coordinate frames, the influence of local frame orientation and position on the characteristics of the resultant kinematic signals has been previously proven to be a major limitation.
View Article and Find Full Text PDF[Access to and Transitions within the Medical Care Process of Persons with Down Syndrome and Dementia: A Qualitative Analysis].
Gesundheitswesen
January 2025
Lehrstuhl für Medizinmanagement, Universität Duisburg-Essen, Essen, Germany.
Compared to the general population, individuals with Down syndrome carry a much higher genetic risk of developing early onset Alzheimer's dementia. This leads to unique challenges and the need for a targeted patient journey.In a qualitative interview study with medical professionals, patient organisations and formal and informal care persons, we assessed barriers within the medical care process of this patient group as well as current approaches to overcome these problems.
View Article and Find Full Text PDFTowards circular desalination: A new methodology for measuring and assessing resource flows and circular actions.
Water Res
January 2025
Department of Civil and Environmental Engineering, Imperial College London, United Kingdom. Electronic address:
There is a lack of methodologies that quantitatively measure the intrinsic circularity of desalination systems, particularly focusing on resource flow traceability and circular actions. This study proposes a novel framework for assessing the circular economy performance of desalination systems. By integrating a systemic indicator selection and calculation approach, this methodology enables a comprehensive evaluation of intrinsic circularity in desalination processes.
View Article and Find Full Text PDFPatient and public involvement in the design and protocol development for a platform randomised trial to evaluate diagnostic tests to optimise antimicrobial therapy (PROTECT).
NIHR Open Res
September 2024
Centre for Trials Research, Cardiff University, Cardiff, Wales, CF14 4YS, UK.
Background: Our patient and public involvement activities were part of a project aiming to develop a master protocol and National Institute for Health and Care research application for the PROTECT trial aiming to assess the effectiveness, implementation, and efficiency of antimicrobial stewardship interventions, to safely reduce unnecessary antibiotic usage by excluding severe bacterial infection in acutely unwell patients.
Methods: Three public involvement sessions were held with representation from young people and parents, people from diverse backgrounds and people with experience of presenting to the emergency department with undifferentiated illness. The teleconference meetings lasted between 60-90 minutes, were recorded, notes were subsequently taken, and findings summarised.
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