AI Article Synopsis
- CCM3/PDCD10 is a gene associated with cerebral cavernous malformations (CCM) that interacts with GCKIII protein kinases (MST3, SOK1, MST4).
- GCKIII proteins have similar effects as CCM3 in endothelial cells and in animal models like zebrafish, indicating their likely role in CCM development.
- The study introduces an in vitro kinase assay for GCKIII proteins to explore their regulation in endothelial and other cell types under various conditions.
Article Abstract
One of the CCM genes, CCM3/PDCD10, binds to the protein kinase family GCKIII, which comprises MST3/STK24, SOK1/STK25, and MST4/STK26. These proteins have been shown to have the same effect as CCM3, both in endothelial cells and in animal models such as zebrafish and are most likely involved in CCM pathogenesis. We describe here an in vitro kinase assay of GCKIII proteins which can be used to study their regulation in endothelial and other cells under different circumstances.
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| http://dx.doi.org/10.1007/978-1-0716-0640-7_32 | DOI Listing |
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